Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
A Comprehensive Overview of Allergen-Specific Immunotherapy Types, Recombinant and Natural Extract Allergens in the Diagnosis and Treatment of Allergies Publisher Pubmed



Moghanloo SA1, 2 ; Forouzanfar M1 ; Jafarinia M1 ; Fazlollahi MR2 ; Kardar GA2, 3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Genetics, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
  2. 2. Immunology, Asthma and Allergy Research Institute (IAARI), Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Allergy# Asthma and Immunology Published:2022


Abstract

Allergen-specific immunotherapy (AIT) involves administering allergen extracts. It is used to desensitize allergic patients. Herbal allergen extracts that are optimum in efficacy and fewest in side effects are still challenging to produce. To overcome these limitations, oral immunotherapy, epicutaneous immunotherapy, intralymphatic immunotherapy, and artificial recombinant allergen preparations have been evaluated. Recombinant allergens have become more popular with the development of molecular diagnostics and therapeutics. Besides food and drug allergens, pollen, fungal spores, and other allergens have been studied. Based on related clinical studies, this comprehensive overview will present the latest perspectives on AIT methods and available allergenic products, as well as discuss the challenges and opportunities for treating allergic disorders. Copyright © 2022 Asoudeh Moghanloo et al.
Related Docs
1. Decorating and Loading Ghosts With Allergens for Allergen Immunotherapy, Human Vaccines and Immunotherapeutics (2017)
2. Design and Evaluation of a Hypoallergenic Peptide-Based Vaccine for Salsola Kali Allergy, International Immunopharmacology (2019)
3. Construction of a Recombinant B-Cell Epitope Vaccine Based on a Der P1-Derived Hypoallergen: A Bioinformatics Approach, Immunotherapy (2018)
4. Allergen-Specific Immunotherapy by Recombinant Der P1 Allergen-Derived Peptide-Based Vaccine in an Allergic Mouse Model, Immunity# Inflammation and Disease (2023)
5. Asthma and Allergy, Clinical Immunology (2022)
6. Expression of Recombinant Parvalbumin From Wolf-Herring Fish and Determination of Its Ige-Binding Capability, Food and Agricultural Immunology (2017)
Experts (# of related papers)
View all Related Experts
Gholamali Kardar (5)
Mohammad Reza Fazlollahi (3)