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The Growth of Preantral Follicles and the Impact of Different Supplementations and Circumstances: A Review Study With Focus on Bovine and Human Preantral Follicles Publisher Pubmed



Rajabi Z1, 2 ; Khokhar Z3 ; Yazdekhasti H4, 5
Authors
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Authors Affiliations
  1. 1. Department of Anatomy, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States
  3. 3. Department of Cell Biology, University of Virginia, Charlottesville, VA, United States
  4. 4. Center for Research in Contraception and Reproductive Health, University of Virginia, Charlottesville, VA, United States
  5. 5. Center for Membrane and Cell Physiology, Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, 22908, VA, United States

Source: Cellular Reprogramming Published:2018


Abstract

One of the most important concerns cancer survivors face is fertility. Current treatment modalities often result in damage to the reproductive system. Different options have been proposed to preserve the fertility of affected women, and many attempts have been made to improve their chance of childbearing after therapy. Cryopreservation of ovarian tissue and follicles before the onset of cancer treatment and then either transplantation of ovarian tissue or culture of ovarian tissue and individual follicles in vitro is a commonly cited approach. Extensive research is being done to design an optimal condition for the culture of ovarian follicles. Improving follicle culture systems by understanding their actual growth needs might be a crucial step toward fertility preservation in cancer patients. This review article will try to provide a summary of the role of different factors and conditions on growth of human and bovine preantral follicles in vitro. © Copyright 2018, Mary Ann Liebert, Inc. 2018.
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