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Germline Cells Derived From Mesenchymal Stem Cells, With the Focus on Wharton's Jelly Publisher



Yazdekhasti H1 ; Hosseini J2 ; Rajabi Z3, 4 ; Shirzeyli M5 ; Aliakbari F5
Authors
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Authors Affiliations
  1. 1. Department of Cell Biology, Center for Research in Contraceptive and Reproductive Health, University of Virginia, Charlottesville, 22908, VA, United States
  2. 2. Infertility and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Biomedical Engineering, University of Virginia, Charlottesville, 22908, VA, United States
  5. 5. Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Asian Pacific Journal of Reproduction Published:2018


Abstract

Previous attempts have indicated that mesenchymal stem cells (MSCs) are a valuable source and candidate and new approach for tissue engineering and reproductive medicine. MSCs have this potential to be induced and differentiated in an appropriate in vivo and in vitro condition toward various cell lineages and then they can be applied in cell therapies and clinical applications. During recent two decades, various sources have demonstrated they are a great source for MSCs, including bone marrow, the human umbilical cord as well as Wharton's jelly. Due to discarding after birth, easily accessible cells and less ethical concerns, these cells have attracted more and more scientists' attention. Infertility and reproduction diseases have provided special opportunity to examine the efficiency of MSCs in this kind of application. Based on recent investigations, MSCs embedded in Wharton's jelly tissue are more appealing for cell therapies, especially in infertility treatment purposes. So, differentiation of MSCs embedded in Wharton's jelly tissue into germ layer cells for cell-based therapy purposes is now under intensive study. © 2018 Asian Pacific Journal of Reproduction Produced by Wolters Kluwer.
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