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Female Fertility Preservation, Clinical and Experimental Options



Rajabi Z1, 2 ; Aliakbari F3 ; Yazdekhasti H2, 4
Authors
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Authors Affiliations
  1. 1. Department of Biomedical Engineering, University of Virginia, Virginia, United States
  2. 2. Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Infertility and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Molecular Physiology and Biological Physics, Center for Membrane and Cell Physiology, University of Virginia, Virginia, United States

Source: Journal of Reproduction and Infertility Published:2018

Abstract

Recently, due to tremendous progress in prognosis, diagnosis, and treatment of different kinds of malignancies, demands on fertility preservation were raised significantly in developed countries. Fertility failure is one of the most detrimental consequences of radio/cytotoxic treatment procedures in women who could overcome their cancer disease. For women who are involved in cancer diseases, there are multiple options regarding their fertility preservation and those could be selected according to patient’s age, the risk of ovarian involvement, the available time and the type of cancer with different levels of advantages and disadvantages. Although there are multiple options, but embryo cryopreservation and ovarian tissue cryopreservation are the most reliable methods for per-mature and post-mature puberty, respectively. In addition, other approaches like artificial ovary, isolation and cryopreservation of follicles and mature and immature oocyte preservation are under investigations and the success rate of oocyte vitrification is increasing. Therefore, the techniques have the potential to be used in clinic in near future. The presence of comprehensive consultation, before the onset of any kind of cancer treatment procedures, is an indispensable issue which would help patients to make up their mind in choosing the immediate and the best available fertility preservation option. © 2018 Avicenna Research Institute. All rights reserved.
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