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The Role of 1H-Mrs and [18F]Fdg Pet/Ct in Differentiating Primary Squamous Cell Carcinoma and Metastatic Hodgkin's Lymphoma in Lung: An Experimental Pilot Study Publisher



Ebrahimi M1, 2 ; Bitarafanrajabi A3, 4 ; Paymani Z5 ; Fardesfahani A6 ; Kooranifar S7 ; Zaresadeghi A1, 2 ; Raminfard S8 ; Nazari M5
Authors
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Authors Affiliations
  1. 1. Medical Physics Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Fintech in Medicine Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Echocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Cardiovascular Interventional Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Nuclear Medicine Department, Children Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Hazrat-e Rasool Hospital, Iran University of Medical Sciences, Tehran, Iran
  8. 8. Advanced Diagnostic and Interventional Radiology Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Nuclear Medicine Published:2024


Abstract

Introduction: Distinguishing the cellular origin of lung cancer is essential for tailored patient care. This pioneering pilot study explores the synergy of 1H-Magnetic Resonance Spectroscopy (1H-MRS) and 2-[18F] fluoro-2-deoxy-Dglucose positron emission tomography/computed tomography ([18F]FDG PET/CT) in the differentiation of primary squamous cell carcinoma (SCC) of the lung from Hodgkin's lymphoma (HL) metastases. Methods: Ethically approved, the study enrolled 21 participants with confirmed lung lesions (10 SCC, 11 HL). [18F]FDG PET/CT and 1H-MRS were conducted, and analyses were performed to assess diagnostic potential. Results: Significant differences in [18F]FDG PET/CT parameters (SUVmax BSA, SUVmax LBM, and ID%) between SCC and HL were observed. Metabolite concentrations (Cho, Lac, Cr) from 1H-MRS also exhibited distinctions. Correlations between PET values and metabolite concentrations hinted at links between glucose metabolism and molecular composition. Conclusion: This study presents an innovative approach, integrating 1H-MRS and [18F]FDG PET/CT to distinguish primary from metastatic lung lesions. The results hold promise for improving non-invasive diagnostic accuracy and guiding targeted therapies. Future research should validate these findings and explore the potential for clinical integration. Copyright © 2024 The Authors.