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Investigation of Sars-Cov-2 Ability to Pass Through the Placenta Publisher



Ghotbizadeh F1 ; Nazari F2 ; Hantoushzadeh S1 ; Panahi Z1 ; Naeiji Z3
Authors
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Authors Affiliations
  1. 1. Department of Obstetrics and Gynecology, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Obstetrics and Gynecology, Bushehr University of Medical Sciences, Bushehr, Iran
  3. 3. Department of Obstetrics and Gynecology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Shiraz E Medical Journal Published:2021


Abstract

Context: Recently, a new coronavirus (SARS-CoV-2) as the cause of COVID-19 has made a global health crisis and a great challenge. Pregnant women and fetuses are among the high-risk groups for COVID-19. In this review, we summarize studies regarding SARS-CoV-2 virus-placenta interactions at the maternal-fetal interface by demonstrating the pathogenicity of the virus and defense methods of the placenta. Evidence Acquisition: In the present study, a search was done in domestic and international databases including Google Scholar, Web of Science, PubMed, and Scopus using specific keywords (“Coronavirus” OR “COVID-19” OR “SARS-CoV-2”) AND (“Fetus” OR “Pla-centa”) AND (“Pregnancy”), limited until August 2020. Finally, we reviewed 250 articles. Results: Generally, the pathogenicity and the life cycle of SARS-CoV-2 and virus entry and replication methods allow the virus to pass through the placenta, although there are hormonal and immune barriers in the placenta against SARS-CoV-2, such as placental type interferons. Conclusions: The SARS-CoV-2 can pass through the placenta, but there are defense methods against it. © 2021, Author(s).
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