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Nano-Delivery System Targeting to Cancer Stem Cell Cluster of Differentiation Biomarkers Publisher Pubmed



Mokhtarzadeh A1, 2 ; Hassanpour S2 ; Vahid ZF3 ; Hejazi M4 ; Hashemi M5 ; Ranjbari J6 ; Tabarzad M7 ; Noorolyai S2 ; De La Guardia M8
Authors
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Authors Affiliations
  1. 1. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Department of Biochemistry, Higher Education Institute of Rab-Rashid, Tabriz, Iran
  3. 3. Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
  4. 4. Zabol University of Medical Sciences, Zabol, Iran
  5. 5. Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  6. 6. Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Protein Technology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Department of Analytical Chemistry, University of Valencia, Dr. Moliner 50, Burjassot, 46100, Valencia, Spain

Source: Journal of Controlled Release Published:2017


Abstract

Cancer stem cells (CSCs) are one of the most important origins of cancer progression and metastasis. CSCs have unique self-renewal properties and diverse cell membrane receptors that induced the resistance to the conventional chemotherapeutic agents. Therefore, the therapeutic removal of CSCs could result in the cancer cure with lack of recurrence and metastasis. In this regard, targeting CSCs in accordance to their specific biomarkers is a talented attitude in cancer therapy. Various CSCs surface biomarkers have been described, which some of them exhibited similarities on different cancer cell types, while the others are cancer specific and have just been reported on one or a few types of cancers. In this review, the importance of CSCs in cancer development and therapeutic response has been stated. Different CSCs cluster of differentiation (CD) biomarkers and their specific function and applications in the treatment of cancers have been discussed, Special attention has been made on targeted nano-delivery systems. In this regard, several examples have been illustrated concerning specific natural and artificial ligands against CSCs CD biomarkers that could be decorated on various nanoparticulated drug delivery systems to enhance therapeutic index of chemotherapeutic agents or anticancer gene therapy. The outlook of CSCs biomarkers discovery and therapeutic/diagnostic applications was discussed. © 2017 Elsevier B.V.
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