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Predictive and Therapeutic Biomarkers in Chimeric Antigen Receptor T-Cell Therapy: A Clinical Perspective Publisher Pubmed



Mirzaei HR1 ; Mirzaei H2 ; Namdar A3 ; Rahmati M4 ; Till BG5 ; Hadjati J1
Authors
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Authors Affiliations
  1. 1. Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashahd, Iran
  3. 3. Department of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada
  4. 4. Cancer Prevention Research Center, Shahroud University of Medical Sciences, Shahroud, Iran
  5. 5. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States

Source: Journal of Cellular Physiology Published:2019


Abstract

The adoptive transfer of genetically engineered T cells modified to express a chimeric antigen receptor (CAR) has shown remarkable activity and induces long-term remissions in patients with advanced hematologic malignancies. To date, little is known about predictive indicators of therapeutic efficacy or serious toxicity after CAR T-cell therapy in clinical practice. Biomarkers are not only potentially able to inform physicians and researchers of immunotherapy targets in particular but could also be used to monitor the effectiveness of treatments and to predict incidence of side effects in some circumstances. Identification of new biomarkers can therefore not only contribute to the development of new therapeutic and prognostic strategies for CAR T-cell therapy for cancer but also help to generate improved clinical practices for early recognition and minimization of adverse effects while preserving the antitumor activity of the CAR T cells. Herein, we will consider a variety of predictive and therapeutic biomarkers in CAR T-cell therapy and the state of current understanding of their clinical utility. The incorporation of biomarker studies in CAR T-cell clinical trials and practice will help to realize the potential clinical benefit of biomarker-guided therapy. © 2018 Wiley Periodicals, Inc.
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