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Covid-19 in Adults With Congenital Heart Disease Publisher Pubmed



Broberg CS1 ; Kovacs AH1 ; Sadeghi S2 ; Rosenbaum MS3 ; Lewis MJ3 ; Carazo MR4 ; Halpern DG5 ; Feinberg J5 ; Galilea FA6 ; Baraona F6 ; Cedars AM7 ; Ko JM7 ; Porayette P8 ; Maldonado J8 Show All Authors
Authors
  1. Broberg CS1
  2. Kovacs AH1
  3. Sadeghi S2
  4. Rosenbaum MS3
  5. Lewis MJ3
  6. Carazo MR4
  7. Halpern DG5
  8. Feinberg J5
  9. Galilea FA6
  10. Baraona F6
  11. Cedars AM7
  12. Ko JM7
  13. Porayette P8
  14. Maldonado J8
  15. Sarubbi B9
  16. Fusco F9
  17. Frogoudaki AA10
  18. Nir A11
  19. Chaudhry A12
  20. John AS13
  21. Karbassi A14
  22. Hoskoppal AK15
  23. Frischhertz BP16
  24. Hendrickson B17
  25. Bouma BJ18
  26. Rodriguezmonserrate CP19
  27. Broda CR20
  28. Tobler D21
  29. Gregg D22
  30. Martinezquintana E23
  31. Yeung E24
  32. Krieger EV25
  33. Rupertirepilado FJ26
  34. Giannakoulas G27
  35. Lui GK28
  36. Ephrem G29
  37. Singh HS30
  38. Almeneisi HM31
  39. Bartlett HL32
  40. Lindsay I33
  41. Grewal J34
  42. Nicolarsen J35
  43. Araujo JJ36
  44. Cramer JW37
  45. Bouchardy J38
  46. Al Najashi K39
  47. Ryan K40
  48. Alshawabkeh L41
  49. Andrade L42
  50. Ladouceur M43
  51. Schwerzmann M44
  52. Greutmann M45
  53. Meras P46
  54. Ferrero P47
  55. Dehghani P48
  56. Tung PP49
  57. Garciaorta R50
  58. Tompkins RO51
  59. Gendi SM52
  60. Cohen S53
  61. Klewer S54
  62. Hascoet S55
  63. Mohammadzadeh S56
  64. Upadhyay S57
  65. Fisher SD58
  66. Cook S59
  67. Cotts TB60
  68. Aboulhosn JA2

Source: Journal of the American College of Cardiology Published:2021


Abstract

Background: Adults with congenital heart disease (CHD) have been considered potentially high risk for novel coronavirus disease-19 (COVID-19) mortality or other complications. Objectives: This study sought to define the impact of COVID-19 in adults with CHD and to identify risk factors associated with adverse outcomes. Methods: Adults (age 18 years or older) with CHD and with confirmed or clinically suspected COVID-19 were included from CHD centers worldwide. Data collection included anatomic diagnosis and subsequent interventions, comorbidities, medications, echocardiographic findings, presenting symptoms, course of illness, and outcomes. Predictors of death or severe infection were determined. Results: From 58 adult CHD centers, the study included 1,044 infected patients (age: 35.1 ± 13.0 years; range 18 to 86 years; 51% women), 87% of whom had laboratory-confirmed coronavirus infection. The cohort included 118 (11%) patients with single ventricle and/or Fontan physiology, 87 (8%) patients with cyanosis, and 73 (7%) patients with pulmonary hypertension. There were 24 COVID-related deaths (case/fatality: 2.3%; 95% confidence interval: 1.4% to 3.2%). Factors associated with death included male sex, diabetes, cyanosis, pulmonary hypertension, renal insufficiency, and previous hospital admission for heart failure. Worse physiological stage was associated with mortality (p = 0.001), whereas anatomic complexity or defect group were not. Conclusions: COVID-19 mortality in adults with CHD is commensurate with the general population. The most vulnerable patients are those with worse physiological stage, such as cyanosis and pulmonary hypertension, whereas anatomic complexity does not appear to predict infection severity. © 2021 American College of Cardiology Foundation
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