A Multicenter Retrospective Study of Clinical Features, Laboratory Characteristics, and Outcomes of 166 Hospitalized Children With Coronavirus Disease 2019 (Covid-19): A Preliminary Report From Iranian Network for Research in Viral Diseases (Inrvd)

A Multicenter Retrospective Study of Clinical Features, Laboratory Characteristics, and Outcomes of 166 Hospitalized Children With Coronavirus Disease 2019 (Covid-19): A Preliminary Report From Iranian Network for Research in Viral Diseases (Inrvd) Publisher Pubmed

Sedighi I^{1, 2} ; Fahimzad A^{2, 3} ; Pak N^{2, 4} ; Khalili M^{2, 5} ; Shokrollahi MR^{2, 6} ; Heydari H^{2, 6} ; Movahedi Z^{2, 6} ; Dashti AS^{2, 7} ; Cheraghali F^{2, 8} ; Shamsizadeh A^{2, 9} ; Mirkarimi M^{2, 9} ; Alisamir M^{2, 9} ; Hashemian H^{2, 10} ; Soltani J^{2, 11} Show All Authors

Sedighi I^{1, 2}
Fahimzad A^{2, 3}
Pak N^{2, 4}
Khalili M^{2, 5}
Shokrollahi MR^{2, 6}
Heydari H^{2, 6}
Movahedi Z^{2, 6}
Dashti AS^{2, 7}
Cheraghali F^{2, 8}
Shamsizadeh A^{2, 9}
Mirkarimi M^{2, 9}
Alisamir M^{2, 9}
Hashemian H^{2, 10}
Soltani J^{2, 11}
Hosseininasab A^{2, 12}
Hamedi A^{2, 20}
Rezai MS^{2, 21}
Sayyahfar S^{2, 22}
Kahbazi M^{2, 23}
Abedini A^{2, 24}
Akhondzadeh A^{2, 25}
Sherkatolabbasieh HR^{2, 26}
Razlansari AA^{2, 26}
Alibeik M^{2, 27}
Malayeri SO^{2, 28}
Shalchi Z^{1, 2}
Shahabinezhad A^{2, 29}
Asl PK^{2, 19}
Monfared FN^{2, 13}
Maleki S^{2, 14}
Kakavand R^{2, 14}
Farahmand M^{2, 13}
Shahbaz B^{2, 13}
Tavakoli A^{2, 15, 22}
Rezayat SA^{2, 16}
Karimi MR^{2, 17}
Erfani Y^{2, 17}
Jafarpour A^{2, 13, 18}
Soltani S^{2, 13, 18}
Zandi M^{2, 13, 18}
Ghaziasadi A^{2, 13, 18}
Dowran R^{2, 13, 18}
Azimi S^{2, 18}
Marvi SS^{2, 13, 18}
Abazari MF^{2, 18}
Norouzi M^{2, 13, 18}
Azhar IR^{2, 13, 18}
Jazayeri SM^{2, 13, 18}

Show Affiliations

1. Department of Pediatric, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2. Iranian Network for Research in Viral Diseases (INRVD), Iran
3. Pediatric Infectious Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Children Medical Centre of Excellence, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Radiology, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6. Pediatric Medicine Research Center, Qom University of Medical Sciences, Qom, Iran
7. Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
8. Department of Pediatric, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
9. Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
10. Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
11. Department of Pediatrics, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
12. Infectious and Tropical Research Center, Kerman University of Medical Sciences, Kerman, Iran
13. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
14. Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
15. Department of Medical Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
16. Department of Health Care Management and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
17. Department of Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
18. Research Center For Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran
19. International Branch, Golestsn University of Medical Sciences, Gorgan, Iran
20. Infection Control Hand and Hygiene Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
21. Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
22. Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran
23. Infectious Diseases Research Center (IDRC), Arak University of Medical Sciences, Arak, Iran
24. Department of Pediatric Infectious Disease, Faculty of Medicine, Children, Clinical Research Development Center, Tabriz University of Medical Sciences, Tabriz, Iran
25. Department of Pediatrics, Arak University of Medical Sciences, Arak, Iran
26. Department of Pediatrics, Lorestan University of medical Sciences, Khorramabad, Iran
27. Pediatric Infectious Diseases Research Center, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
28. Health Clinical Sciences Research Center, Zahedan Branch, Islamic Azad University, Zahedan, Iran
29. Joint Reconstruction Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Pediatric Pulmonology Published:2022

Abstract

Background: The objectives of this study were to analyze the clinical features and laboratory profiles and risk factors associated with critical illness of children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods: One hundred and sixty-six coronavirus disease 2019 (COVID-19) Iranian pediatric patients were recruited through a collaborative research network between March and May 2020. Demographics, clinical, laboratory, and radiological results were obtained from patient files. Results: Of 166 patients, 102 (61%) and 64 (39%) were males and females, respectively. Ninety-six (57.8%) and 70 (42.2%), had moderate and severe conditions, respectively. Thirty (18%) of patients died. The common symptoms were fever (73%), cough (54%), and shortness of breath, headache decrease in neutrophil and platelet counts; increase values in lactate dehydrogenase, decrease in the blood pH and HCO3 were significantly associated with the disease severity. 54% and 56% of patients showed abnormal radiographic appearance in Chest X-ray and in chest computed tomography scan, respectively. Sixty-one (36.7%) of patients were referred to intensive care unit (ICU). The coexistence of comorbidity was the main factor associated with ICU admission, shock, arrhythmia, acute kidney injury, acute respiratory distress syndrome, acute cardiac injury, and death. Conclusions: We describe a higher than previously recognized rate of COVID-19 mortality in Iranian pediatric patients. Epidemiological factors, such as the relatively high case fatality rate in the country and the presence of underlying diseases were the main factors for the high death rate. © 2021 Wiley Periodicals LLC

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Style	Citing Format
MLA	Sedighi I, et al.. "A Multicenter Retrospective Study of Clinical Features, Laboratory Characteristics, and Outcomes of 166 Hospitalized Children With Coronavirus Disease 2019 (Covid-19): A Preliminary Report From Iranian Network for Research in Viral Diseases (Inrvd)." Pediatric Pulmonology, vol. 57, no. 2, 2022, pp. 498-507.
APA	Sedighi I, Fahimzad A, Pak N, Khalili M, Shokrollahi MR, Heydari H, Movahedi Z, Dashti AS, Cheraghali F, Shamsizadeh A, Mirkarimi M, Alisamir M, Hashemian H, Soltani J, Hosseininasab A, Hamedi A, Rezai MS, Sayyahfar S, Kahbazi M, ... Jazayeri SM (2022). A Multicenter Retrospective Study of Clinical Features, Laboratory Characteristics, and Outcomes of 166 Hospitalized Children With Coronavirus Disease 2019 (Covid-19): A Preliminary Report From Iranian Network for Research in Viral Diseases (Inrvd). Pediatric Pulmonology, 57(2), 498-507.
Chicago	Sedighi I, Fahimzad A, Pak N, Khalili M, Shokrollahi MR, Heydari H, Movahedi Z, et al.. "A Multicenter Retrospective Study of Clinical Features, Laboratory Characteristics, and Outcomes of 166 Hospitalized Children With Coronavirus Disease 2019 (Covid-19): A Preliminary Report From Iranian Network for Research in Viral Diseases (Inrvd)." Pediatric Pulmonology 57, no. 2 (2022): 498-507.
Harvard	Sedighi I et al. (2022) 'A Multicenter Retrospective Study of Clinical Features, Laboratory Characteristics, and Outcomes of 166 Hospitalized Children With Coronavirus Disease 2019 (Covid-19): A Preliminary Report From Iranian Network for Research in Viral Diseases (Inrvd)', Pediatric Pulmonology, 57(2), pp. 498-507.
Vancouver	Sedighi I, Fahimzad A, Pak N, Khalili M, Shokrollahi MR, Heydari H, et al.. A Multicenter Retrospective Study of Clinical Features, Laboratory Characteristics, and Outcomes of 166 Hospitalized Children With Coronavirus Disease 2019 (Covid-19): A Preliminary Report From Iranian Network for Research in Viral Diseases (Inrvd). Pediatric Pulmonology. 2022;57(2):498-507.
BibTex	@article{ author = {Sedighi I and Fahimzad A and Pak N and Khalili M and Shokrollahi MR and Heydari H and Movahedi Z and Dashti AS and Cheraghali F and Shamsizadeh A and Mirkarimi M and Alisamir M and Hashemian H and Soltani J and Hosseininasab A and Hamedi A and Rezai MS and Sayyahfar S and Kahbazi M and Abedini A and Akhondzadeh A and Sherkatolabbasieh HR and Razlansari AA and Alibeik M and Malayeri SO and Shalchi Z and Shahabinezhad A and Asl PK and Monfared FN and Maleki S and Kakavand R and Farahmand M and Shahbaz B and Tavakoli A and Rezayat SA and Karimi MR and Erfani Y and Jafarpour A and Soltani S and Zandi M and Ghaziasadi A and Dowran R and Azimi S and Marvi SS and Abazari MF and Norouzi M and Azhar IR and Jazayeri SM}, title = {A Multicenter Retrospective Study of Clinical Features, Laboratory Characteristics, and Outcomes of 166 Hospitalized Children With Coronavirus Disease 2019 (Covid-19): A Preliminary Report From Iranian Network for Research in Viral Diseases (Inrvd)}, journal = {Pediatric Pulmonology}, volume = {57}, number = {2}, pages = {498-507}, year = {2022} }
RIS	TY - JOUR AU - Sedighi I AU - Fahimzad A AU - Pak N AU - Khalili M AU - Shokrollahi MR AU - Heydari H AU - Movahedi Z AU - Dashti AS AU - Cheraghali F AU - Shamsizadeh A AU - Mirkarimi M AU - Alisamir M AU - Hashemian H AU - Soltani J AU - Hosseininasab A AU - Hamedi A AU - Rezai MS AU - Sayyahfar S AU - Kahbazi M AU - Abedini A AU - Akhondzadeh A AU - Sherkatolabbasieh HR AU - Razlansari AA AU - Alibeik M AU - Malayeri SO AU - Shalchi Z AU - Shahabinezhad A AU - Asl PK AU - Monfared FN AU - Maleki S AU - Kakavand R AU - Farahmand M AU - Shahbaz B AU - Tavakoli A AU - Rezayat SA AU - Karimi MR AU - Erfani Y AU - Jafarpour A AU - Soltani S AU - Zandi M AU - Ghaziasadi A AU - Dowran R AU - Azimi S AU - Marvi SS AU - Abazari MF AU - Norouzi M AU - Azhar IR AU - Jazayeri SM TI - A Multicenter Retrospective Study of Clinical Features, Laboratory Characteristics, and Outcomes of 166 Hospitalized Children With Coronavirus Disease 2019 (Covid-19): A Preliminary Report From Iranian Network for Research in Viral Diseases (Inrvd) JO - Pediatric Pulmonology VL - 57 IS - 2 SP - 498 EP - 507 PY - 2022 ER -

Style

Citing Format

MLA

Sedighi I, et al.. "A Multicenter Retrospective Study of Clinical Features, Laboratory Characteristics, and Outcomes of 166 Hospitalized Children With Coronavirus Disease 2019 (Covid-19): A Preliminary Report From Iranian Network for Research in Viral Diseases (Inrvd)." Pediatric Pulmonology, vol. 57, no. 2, 2022, pp. 498-507.

APA

Sedighi I, Fahimzad A, Pak N, Khalili M, Shokrollahi MR, Heydari H, Movahedi Z, Dashti AS, Cheraghali F, Shamsizadeh A, Mirkarimi M, Alisamir M, Hashemian H, Soltani J, Hosseininasab A, Hamedi A, Rezai MS, Sayyahfar S, Kahbazi M, ... Jazayeri SM (2022). A Multicenter Retrospective Study of Clinical Features, Laboratory Characteristics, and Outcomes of 166 Hospitalized Children With Coronavirus Disease 2019 (Covid-19): A Preliminary Report From Iranian Network for Research in Viral Diseases (Inrvd). Pediatric Pulmonology, 57(2), 498-507.

Chicago

Sedighi I, Fahimzad A, Pak N, Khalili M, Shokrollahi MR, Heydari H, Movahedi Z, et al.. "A Multicenter Retrospective Study of Clinical Features, Laboratory Characteristics, and Outcomes of 166 Hospitalized Children With Coronavirus Disease 2019 (Covid-19): A Preliminary Report From Iranian Network for Research in Viral Diseases (Inrvd)." Pediatric Pulmonology 57, no. 2 (2022): 498-507.

Harvard

Sedighi I et al. (2022) 'A Multicenter Retrospective Study of Clinical Features, Laboratory Characteristics, and Outcomes of 166 Hospitalized Children With Coronavirus Disease 2019 (Covid-19): A Preliminary Report From Iranian Network for Research in Viral Diseases (Inrvd)', Pediatric Pulmonology, 57(2), pp. 498-507.

Vancouver

Sedighi I, Fahimzad A, Pak N, Khalili M, Shokrollahi MR, Heydari H, et al.. A Multicenter Retrospective Study of Clinical Features, Laboratory Characteristics, and Outcomes of 166 Hospitalized Children With Coronavirus Disease 2019 (Covid-19): A Preliminary Report From Iranian Network for Research in Viral Diseases (Inrvd). Pediatric Pulmonology. 2022;57(2):498-507.

BibTex

@article{ author = {Sedighi I and Fahimzad A and Pak N and Khalili M and Shokrollahi MR and Heydari H and Movahedi Z and Dashti AS and Cheraghali F and Shamsizadeh A and Mirkarimi M and Alisamir M and Hashemian H and Soltani J and Hosseininasab A and Hamedi A and Rezai MS and Sayyahfar S and Kahbazi M and Abedini A and Akhondzadeh A and Sherkatolabbasieh HR and Razlansari AA and Alibeik M and Malayeri SO and Shalchi Z and Shahabinezhad A and Asl PK and Monfared FN and Maleki S and Kakavand R and Farahmand M and Shahbaz B and Tavakoli A and Rezayat SA and Karimi MR and Erfani Y and Jafarpour A and Soltani S and Zandi M and Ghaziasadi A and Dowran R and Azimi S and Marvi SS and Abazari MF and Norouzi M and Azhar IR and Jazayeri SM}, title = {A Multicenter Retrospective Study of Clinical Features, Laboratory Characteristics, and Outcomes of 166 Hospitalized Children With Coronavirus Disease 2019 (Covid-19): A Preliminary Report From Iranian Network for Research in Viral Diseases (Inrvd)}, journal = {Pediatric Pulmonology}, volume = {57}, number = {2}, pages = {498-507}, year = {2022} }

RIS

TY - JOUR
AU - Sedighi I
AU - Fahimzad A
AU - Pak N
AU - Khalili M
AU - Shokrollahi MR
AU - Heydari H
AU - Movahedi Z
AU - Dashti AS
AU - Cheraghali F
AU - Shamsizadeh A
AU - Mirkarimi M
AU - Alisamir M
AU - Hashemian H
AU - Soltani J
AU - Hosseininasab A
AU - Hamedi A
AU - Rezai MS
AU - Sayyahfar S
AU - Kahbazi M
AU - Abedini A
AU - Akhondzadeh A
AU - Sherkatolabbasieh HR
AU - Razlansari AA
AU - Alibeik M
AU - Malayeri SO
AU - Shalchi Z
AU - Shahabinezhad A
AU - Asl PK
AU - Monfared FN
AU - Maleki S
AU - Kakavand R
AU - Farahmand M
AU - Shahbaz B
AU - Tavakoli A
AU - Rezayat SA
AU - Karimi MR
AU - Erfani Y
AU - Jafarpour A
AU - Soltani S
AU - Zandi M
AU - Ghaziasadi A
AU - Dowran R
AU - Azimi S
AU - Marvi SS
AU - Abazari MF
AU - Norouzi M
AU - Azhar IR
AU - Jazayeri SM
TI - A Multicenter Retrospective Study of Clinical Features, Laboratory Characteristics, and Outcomes of 166 Hospitalized Children With Coronavirus Disease 2019 (Covid-19): A Preliminary Report From Iranian Network for Research in Viral Diseases (Inrvd)
JO - Pediatric Pulmonology
VL - 57
IS - 2
SP - 498
EP - 507
PY - 2022
ER -

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