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A Multicenter Retrospective Study of Clinical Features, Laboratory Characteristics, and Outcomes of 166 Hospitalized Children With Coronavirus Disease 2019 (Covid-19): A Preliminary Report From Iranian Network for Research in Viral Diseases (Inrvd) Publisher Pubmed



Sedighi I1, 2 ; Fahimzad A2, 3 ; Pak N2, 4 ; Khalili M2, 5 ; Shokrollahi MR2, 6 ; Heydari H2, 6 ; Movahedi Z2, 6 ; Dashti AS2, 7 ; Cheraghali F2, 8 ; Shamsizadeh A2, 9 ; Mirkarimi M2, 9 ; Alisamir M2, 9 ; Hashemian H2, 10 ; Soltani J2, 11 Show All Authors
Authors
  1. Sedighi I1, 2
  2. Fahimzad A2, 3
  3. Pak N2, 4
  4. Khalili M2, 5
  5. Shokrollahi MR2, 6
  6. Heydari H2, 6
  7. Movahedi Z2, 6
  8. Dashti AS2, 7
  9. Cheraghali F2, 8
  10. Shamsizadeh A2, 9
  11. Mirkarimi M2, 9
  12. Alisamir M2, 9
  13. Hashemian H2, 10
  14. Soltani J2, 11
  15. Hosseininasab A2, 12
  16. Hamedi A2, 20
  17. Rezai MS2, 21
  18. Sayyahfar S2, 22
  19. Kahbazi M2, 23
  20. Abedini A2, 24
  21. Akhondzadeh A2, 25
  22. Sherkatolabbasieh HR2, 26
  23. Razlansari AA2, 26
  24. Alibeik M2, 27
  25. Malayeri SO2, 28
  26. Shalchi Z1, 2
  27. Shahabinezhad A2, 29
  28. Asl PK2, 19
  29. Monfared FN2, 13
  30. Maleki S2, 14
  31. Kakavand R2, 14
  32. Farahmand M2, 13
  33. Shahbaz B2, 13
  34. Tavakoli A2, 15, 22
  35. Rezayat SA2, 16
  36. Karimi MR2, 17
  37. Erfani Y2, 17
  38. Jafarpour A2, 13, 18
  39. Soltani S2, 13, 18
  40. Zandi M2, 13, 18
  41. Ghaziasadi A2, 13, 18
  42. Dowran R2, 13, 18
  43. Azimi S2, 18
  44. Marvi SS2, 13, 18
  45. Abazari MF2, 18
  46. Norouzi M2, 13, 18
  47. Azhar IR2, 13, 18
  48. Jazayeri SM2, 13, 18

Source: Pediatric Pulmonology Published:2022


Abstract

Background: The objectives of this study were to analyze the clinical features and laboratory profiles and risk factors associated with critical illness of children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods: One hundred and sixty-six coronavirus disease 2019 (COVID-19) Iranian pediatric patients were recruited through a collaborative research network between March and May 2020. Demographics, clinical, laboratory, and radiological results were obtained from patient files. Results: Of 166 patients, 102 (61%) and 64 (39%) were males and females, respectively. Ninety-six (57.8%) and 70 (42.2%), had moderate and severe conditions, respectively. Thirty (18%) of patients died. The common symptoms were fever (73%), cough (54%), and shortness of breath, headache decrease in neutrophil and platelet counts; increase values in lactate dehydrogenase, decrease in the blood pH and HCO3 were significantly associated with the disease severity. 54% and 56% of patients showed abnormal radiographic appearance in Chest X-ray and in chest computed tomography scan, respectively. Sixty-one (36.7%) of patients were referred to intensive care unit (ICU). The coexistence of comorbidity was the main factor associated with ICU admission, shock, arrhythmia, acute kidney injury, acute respiratory distress syndrome, acute cardiac injury, and death. Conclusions: We describe a higher than previously recognized rate of COVID-19 mortality in Iranian pediatric patients. Epidemiological factors, such as the relatively high case fatality rate in the country and the presence of underlying diseases were the main factors for the high death rate. © 2021 Wiley Periodicals LLC
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