Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
An Overview of Leishmanization Experience: A Successful Control Measure and a Tool to Evaluate Candidate Vaccines Publisher Pubmed



Mohebali M1, 2 ; Nadim A3 ; Khamesipour A4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Parasitology & Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Research Center for Endemic Parasites of Iran, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Continuously member of Academy of Medical Sciences, Tehran, Iran
  4. 4. Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, 14166-13675, Iran

Source: Acta Tropica Published:2019


Abstract

Leishmanization (LZ) is an intradermal inoculation of live Leishmania to induce an artificial cutaneous leishmaniasis (CL) lesion in a covered part of the body to protect against further natural CL lesion development. Leishmanization has been used from ancient times and when NNN medium was developed continued with using Leishmania from culture media. The objective of this study was to review LZ published experiences. This article is a review of LZ experiences and historical studies initiated since 1910 when Leishmania promastigotes were harvested from culture media and used for LZ. This review includes LZ experiences in Israel, some countries of Former Soviet Union and Iran. The results of LZ in Israel, some countries of Former Soviet Union and Iran showed that despite limitations, using this method significantly reduced the incidence rate of CL among leishmanized individuals in endemic areas. In conclusion, leishmanization using Leishmania major produced under GMP guideline is a valuable tool to protect against CL, there are limitations which need further study. © 2019 Elsevier B.V.
Related Docs
View other Related Docs
1. Vaccines for Preventing Cutaneous Leishmaniasis, Cochrane Database of Systematic Reviews (2018)
2. Overexpression of Iron Super Oxide Dismutases A/B Genes Are Associated With Antimony Resistance of Leishmania Tropica Clinical Isolates, Iranian Journal of Parasitology (2022)
3. The Role of Iscomatrix Bilayer Composition to Induce a Cell Mediated Immunity and Protection Against Leishmaniasis in Balb/C Mice, Iranian Journal of Basic Medical Sciences (2016)
4. Pegylation of Cationic Liposomes Encapsulating Soluble Leishmania Antigens Reduces the Adjuvant Efficacy of Liposomes in Murine Model, Parasite Immunology (2017)
5. Treatment Failure in Cutaneous Leishmaniasis Patients Referred to the School of Public Health, Tehran University of Medical Sciences During 2008-2017, Journal of Arthropod-Borne Diseases (2020)
6. Evaluation of Immune Response Against Leishmaniasis in Balb/C Mice Immunized With Cationic Dotap/Dope/Chol Liposomes Containing Soluble Leishmania Major Antigens, Iranian Journal of Parasitology (2019)
7. Cationic Liposomes Formulated With a Novel Whole Leishmania Lysate (Wll) As a Vaccine for Leishmaniasis in Murine Model, Immunobiology (2018)
8. Insights Into the Trypanothione System in Antimony-Resistant and Sensitive Leishmania Tropica Clinical Isolates, Acta Tropica (2024)
Experts (# of related papers)
View all Related Experts
Mahdi Mohebali (40)
Homa Hajjaran (20)
Other Related Docs
9. Photodynamic Therapy Using Toluidine Blue O (Tbo) Dye As a Photosensitizer Against Leishmania Major, Iranian Journal of Public Health (2021)
10. Cationic Immune Stimulating Complexes Containing Soluble Leishmania Antigens: Preparation, Characterization and in Vivo Immune Response Evaluation, Iranian Journal of Immunology (2015)
11. Expression Analysis of Activated Protein Kinase C Gene (Lack1) in Antimony Sensitive and Resistant Leishmania Tropica Clinical Isolates Using Real-Time Rt-Pcr, International Journal of Dermatology (2016)
12. Development of Nano-Carriers for Leishmania Vaccine Delivery, Expert Opinion on Drug Delivery (2020)
13. Upregulation of Antioxidant Genes in Antimony-Resistant Leishmania Tropica Clinical Isolates, Molecular Biology Reports (2025)
14. Live Attenuated Leishmania Major P27 Gene Knockout As a Novel Vaccine Candidate: A Study on Safety, Protective Immunity and Efficacy Against Canine Leishmaniasis Caused by Leishmania Infantum, Acta Tropica (2022)
15. Western Blot Analysis of Leishmania Infantum Antigens in Sera of Patients With Visceral Leishmaniasis, Iranian Journal of Parasitology (2019)
16. Safety Evaluation of Nano-Liposomal Formulation of Amphotericin B (Sina Ampholeish) in Animal Model As a Candidate for Treatment of Cutaneous Leishmaniasis, Journal of Arthropod-Borne Diseases (2018)
17. Gene Expression Analysis of Antimony Resistance in Leishmania Tropica Using Quantitative Real-Time Pcr Focused on Genes Involved in Trypanothione Metabolism and Drug Transport, Archives of Dermatological Research (2019)
18. Comparison of Proteome Profiling of Two Sensitive and Resistant Field Iranian Isolates of Leishmania Major to Glucantime® by 2-Dimensional Electrophoresis, Iranian Journal of Parasitology (2015)
19. Comparison of Cytokine Profile of Ifn-Γ, Il-5 and Il-10 in Cutaneous Leishmaniasis Using Pbmc Vs. Whole Blood, Iranian Journal of Microbiology (2019)
20. Comparison of P27 Gene Expression of Promastigote and Amastigote Forms of Leishmania Major (Mrho/Ir/75/Er) by Real-Time Rt-Pcr, Iranian Journal of Parasitology (2018)
21. The Role of Atp-Binding Cassette Transporter Genes Expression in Treatment Failure Cutaneous Leishmaniasis, AMB Express (2022)
22. Immune Responses in Cutaneous Leishmaniasis: In Vitro Thelper1/Thelper2 Cytokine Profiles Using Live Versus Killed Leishmania Major, Journal of Arthropod-Borne Diseases (2021)
23. Demographic and Clinical Characteristics of Children With Cutaneous Leishmaniasis in Isfahan Province, Iran, During 2011-2015, Journal of Isfahan Medical School (2017)
24. Live Attenuated Leishmania Infantum Centrin Deleted Mutant (Licen-/-) As a Novel Vaccine Candidate: A Field Study on Safety, Immunogenicity, and Efficacy Against Canine Leishmaniasis, Comparative Immunology# Microbiology and Infectious Diseases (2023)
25. Potent Antileishmanial Activity of Chitosan Against Iranian Strain of Leishmania Major (Mrho/Ir/75/Er): In Vitro and in Vivo Assay, Journal of Vector Borne Diseases (2018)
26. The Role of Lpd-Nanoparticles Containing Recombinant Major Surface Glycoprotein of Leishmania (Rgp63) in Protection Against Leishmaniasis in Murine Model, Immunopharmacology and Immunotoxicology (2018)
27. Expression Analysis of Viscerotropic Leishmaniasis Gene in Leishmania Species by Real-Time Rt-Pcr, Acta Parasitologica (2016)
28. Post-Treatment Clinical Outcomes of Cutaneous Leishmaniosis in the Bam Area, South Eastern Iran: Analysis of Over 9,000 Cases, International Journal of Infectious Diseases (2015)
29. An Alphavirus-Derived Self-Amplifying Mrna Encoding Ppsp15-Lmsti1 Fusion Protein for the Design of a Vaccine Against Leishmaniasis, Parasitology International (2022)
30. Potential Biomarkers of Immune Protection in Human Leishmaniasis, Medical Microbiology and Immunology (2021)
31. The Geographical Distribution of Human Cutaneous and Visceral Leishmania Species Identified by Molecular Methods in Iran: A Systematic Review With Meta-Analysis, Frontiers in Public Health (2021)
32. Comparative Expression Profile Analysis of Apoptosis-Related Mirna and Its Target Gene in Leishmania Major Infected Macrophages, Iranian Journal of Parasitology (2020)
33. The Role of Mpl and Imiquimod Adjuvants in Enhancement of Immune Response and Protection in Balb/C Mice Immunized With Soluble Leishmania Antigen (Sla) Encapsulated in Nanoliposome, Artificial Cells# Nanomedicine and Biotechnology (2018)
34. Sphingomyelin Liposome Bearing Whole Leishmania Lysate Antigens Induce Strong Th2 Immune Response in Balb/C Mice, Iranian Journal of Basic Medical Sciences (2021)
35. Correlation Between Clinical Responses With the Drug-Susceptibility of Parasites in Iranian Cutaneous Leishmaniasis Caused by Leishmania Major, Tropical Biomedicine (2017)
36. Visceral Leishmaniasis in Southeastern Iran: A Narrative Review, Iranian Journal of Parasitology (2017)
37. Chitosan-Based Biocompatible Dressing for Treatment of Recalcitrant Lesions of Cutaneous Leishmaniasis: A Pilot Clinical Study, Indian Journal of Dermatology# Venereology and Leprology (2019)
38. Niosomal Formulation of Amphotericin B Alone and in Combination With Glucantime: In Vitro and in Vivo Leishmanicidal Effects, Biomedicine and Pharmacotherapy (2019)
39. Safety Evaluation of Topical Application of Nano-Liposomal Form of Amphotericin B (Sinaampholeish) on Healthy Volunteers: Phase I Clinical Trial, Iranian Journal of Parasitology (2019)
40. Comparative Proteomic Profiling of Leishmania Tropica: Investigation of a Case Infected With Simultaneous Cutaneous and Viscerotropic Leishmaniasis by 2-Dimentional Electrophoresis and Mass Spectrometry, Iranian Journal of Parasitology (2015)
41. A Novel Strategy for Enhance Potentiation of Meglumine Antimoniate Against Leishmania Major in Vitro, Iranian Journal of Parasitology (2019)
42. Analysis of Human B Cell Response to Recombinant Leishmania Lpg3, Asian Pacific Journal of Tropical Medicine (2015)
43. Visceral Leishmaniasis in Rural Areas of Alborz Province of Iran and Implication to Health Policy, Korean Journal of Parasitology (2015)
44. Vector and Reservoir Control for Preventing Leishmaniasis, Cochrane Database of Systematic Reviews (2015)
45. Comparative Mitochondrial Proteomics of Leishmania Tropica Clinical Isolates Resistant and Sensitive to Meglumine Antimoniate, Parasitology Research (2020)
46. Seroprevalence of Visceral Leishmaniasis in Children up to 12 Years Old of Rural Areas From Kermanshah Province, Western Part of Iran, Iranian Journal of Parasitology (2023)
47. Nanoformulating Cinnamomum Zeylanicum Essential Oil With an Extreme Effect on Leishmania Tropica and Leishmania Major, Journal of Drug Delivery Science and Technology (2021)
48. Situation Analysis of Cutaneous Leishmaniasis in an Endemic Area, South of Iran, Asian Pacific Journal of Tropical Medicine (2017)
49. A Comprehensive Review of Cutaneous Leishmaniasis in Kerman Province, Southeastern Iran- Narrative Review Article, Iranian Journal of Public Health (2015)
50. Molecular Identification of Leishmania Species in Phlebotomus Alexandri (Diptera: Psychodidae) in Western Iran, Journal of Arthropod-Borne Diseases (2020)