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Meta-Analysis of Type-Specific Human Papillomavirus Prevalence in Iranian Women With Normal Cytology, Precancerous Cervical Lesions and Invasive Cervical Cancer: Implications for Screening and Vaccination Publisher Pubmed



Jalilvand S1 ; Shoja Z2 ; Nourijelyani K3 ; Tohidi HR4, 5 ; Hamkar R1
Authors
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Authors Affiliations
  1. 1. Virology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Virology Department, Pasteur Institute of Iran, Tehran, Iran
  3. 3. Biostatistics Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Faculty of Health, Gonabad University of Medical Sciences, Gonabad, Iran
  5. 5. Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Science Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Medical Virology Published:2015


Abstract

To predict the impact of current vaccines on cervical cancer and for the improvement of screening programs, regional data on distribution of human papillomavirus (HPV) types in women with or without cervical cancer is crucial. The present meta-analysis intend to comprehensively evaluate the HPV burden in women with invasive cervical cancer, high-grade squamous intraepithelial lesion (cervical intraepithelial neoplasia 2 and 3), low-grade squamous intraepithelial lesion (cervical intraepithelial neoplasia 1), atypical squamous cells of undetermined significance and normal cytology, as these data will help decision making in regards with screening programs and HPV vaccination in Iran. To determine the HPV prevalence and type distribution in Iranian women with or without cervical cancer, 20 published studies were included in this meta-analysis. In total, 713, 124, 104, 60, and 2577 women invasive cervical cancer, high-grade squamous intraepithelial lesion (cervical intraepithelial neoplasia 2 and 3), low-grade squamous intraepithelial lesion (cervical intraepithelial neoplasia 1), atypical squamous cells of undetermined significance and normal were reviewed, respectively. Overall HPV prevalence in women with invasive cervical cancer, high-grade squamous intraepithelial lesion (cervical intraepithelial neoplasia 2 and 3), low-grade squamous intraepithelial lesion (cervical intraepithelial neoplasia 1), atypical squamous cells of undetermined significance and normal cytology were 77.4%, 71.8%, 65.3%, 61.7%, and 8.4%, respectively. The six most common types were HPV 16, 18, 6/11, 31, and 33; among them HPV 16 was the most frequent type in all five different groups. According to this study, it was estimated that HPV vaccines could have a great impact on prevention of cervical cancer in Iran. In conclusion, this meta-analysis highlights the necessity of introducing vaccination program in Iran. J. Med. Virol. 87:287-295, 2015. © 2014 Wiley Periodicals, Inc.
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