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The Potential Use of Antibiotics Against Helicobacter Pylori Infection: Biopharmaceutical Implications Publisher



Miri AH1, 2 ; Kamankesh M3 ; Llopislorente A4 ; Liu C5 ; Wacker MG6 ; Haririan I1 ; Asadzadeh Aghdaei H7 ; Hamblin MR8 ; Yadegar A2 ; Radmalekshahi M1 ; Zali MR9
Authors
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Authors Affiliations
  1. 1. Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Polymer Chemistry Department, School of Science, University of Tehran, Tehran, Iran
  4. 4. Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, Netherlands
  5. 5. College of Marine Life Science, Ocean University of China, Qingdao, China
  6. 6. Department of Pharmacy, National University of Singapore, Singapore, Singapore
  7. 7. Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, South Africa
  9. 9. Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Frontiers in Pharmacology Published:2022


Abstract

Helicobacter pylori (H. pylori) is a notorious, recalcitrant and silent germ, which can cause a variety of debilitating stomach diseases, including gastric and duodenal ulcers and gastric cancer. This microbe predominantly colonizes the mucosal layer of the human stomach and survives in the inhospitable gastric microenvironment, by adapting to this hostile milieu. In this review, we first discuss H. pylori colonization and invasion. Thereafter, we provide a survey of current curative options based on polypharmacy, looking at pharmacokinetics, pharmacodynamics and pharmaceutical microbiology concepts, in the battle against H. pylori infection. Copyright © 2022 Miri, Kamankesh, Llopis-Lorente, Liu, Wacker, Haririan, Asadzadeh Aghdaei, Hamblin, Yadegar, Rad-Malekshahi and Zali.
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