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A Highly Sensitive Biosensor Based on Methacrylated Graphene Oxide-Grafted Polyaniline for Ascorbic Acid Determination Publisher



Naghib SM1 ; Behzad F2 ; Rahmanian M3 ; Zare Y3 ; Rhee KY4
Authors
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Authors Affiliations
  1. 1. Nanotechnology Department, School of Advanced Technologies, Iran University of Science and Technology, Tehran, Iran
  2. 2. Research institute of bioscience and biotechnology, University of Tabriz, Tabriz, Iran
  3. 3. Department of Interdisciplinary Technologies, Biomaterials and Tissue Engineering Research Group, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
  4. 4. Department of Mechanical Engineering, College of Engineering, Kyung Hee University, Yongin, 446-701, South Korea

Source: Nanotechnology Reviews Published:2020


Abstract

Functionalized graphene-based nanocomposites have opened new windows to address some challenges for increasing the sensitivity, accuracy and functionality of biosensors. Polyaniline (PANI) is one of the most potentially promising and technologically important conducting polymers, which brings together the electrical features of metals with intriguing properties of plastics including facile processing and controllable chemical and physical properties. PANI/graphene nanocomposites have attracted intense interest in various fields due to unique physicochemical properties including high conductivity, facile preparation and intriguing redox behavior. In this article, a functionalized graphene-grafted nanostructured PANI nanocomposite was applied for determining the ascorbic acid (AA) level. A significant current response was observed after treating the electrode surface with methacrylated graphene oxide (MeGO)/PANI nanocomposite. The amperometric responses showed a robust linear range of 8-5,000 μM and detection limit of 2 μM (N = 5). Excellent sensor selectivity was demonstrated in the presence of electroactive components interfering species, commonly found in real serum samples. This sensor is a promising candidate for rapid and selective determination of AA. © 2020 Seyed Morteza Naghib et al., published by De Gruyter 2020.
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