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A Novel Graphene-Grafted Gold Nanoparticles Composite for Highly Sensitive Electrochemical Biosensing Publisher



Salahandish R1 ; Ghaffarinejad A1 ; Naghib SM2 ; Majidzadeha K3 ; Sanatinezhad A4
Authors
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Authors Affiliations
  1. 1. Research Laboratory of Real Samples Analysis, Electroanalytical Chemistry Research Center, Iran University of Science and Technology, Tehran, 1684613114, Iran
  2. 2. Nanothechnology Department, School of New Technologies, Iran University of Science and Technology, Tehran, 16846-13114, Iran
  3. 3. Breast Cancer Research Center, Genetics Department, Motamed Cancer Institute, Tehran, 14155-4364, Iran
  4. 4. BioMEMS and Bioinspired Microfluidic Laboratory, Department of Mechanical and Manufacturing Engineering, University of Calgary, Calgary, T2N 1N4, AB, Canada

Source: IEEE Sensors Journal Published:2018


Abstract

The use of affordable amendments required increasing the sensitivity and functionality of electrochemical devices is still challenging. Novel scalable, gold nanoparticles-grafted nitrogen-doped graphene nanostructured polyaniline nanocomposites were stupendously developed in this paper. The charge transfer resistance was dramatically decreased from 11000 Ω (for bare fluorine doped tin oxide electrode) down to 115 Ω (for the nanocomposite-modified electrode). The present nanocomposites provided a superb opportunity for the design of electrochemical biosensors with extraordinary performance via enhanced analyte sensitivity for the detection of ascorbic acid (0.640 mM detection limit at signal to noise ratio = 3, and two linear ranges of 0.96-4.66 and 5.06-9.86 mM with the sensitivity of 10.44 and 28.91μA.mM-1. cm-2 , respectively), and high selectivity over electroactive components interfering species, commonly found in real serum samples. © 2001-2012 IEEE.
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