Investigation of Nudt15 Allele Frequency in a Group of Iranian Population



N Sarhangi NEGAR ; M Hasanzad MANDANA ; F Rouhollah FARAJZADEH ; S Nikfar SHEKOUFEH ; F Sharifi FARSHAD ; N Niknam NEGAR
Source: Iranian Journal of Diabetes and Metabolism Published:2025

Abstract

Background: Pharmacogenomics (PGx), as a growing field of personalized medicine, aims to optimize the efficacy and safety of medications by studying the association between germline genetic variations and drug responses. The present cross-sectional study aims to evaluate the allele frequency of the NUDT15 genetic variant in the Iranian population to provide insights into personalized treatment decisions in the Iranian population. Methods: A representative sample set of 1142 unrelated healthy Iranian individuals aged 18 and older genotyped using the Infinium Global Screening Array-24 BeadChip. Results: We identified a pharmacogenetic variant with minor allele frequency (MAF) ≥1% among the present studied population which may explain the substantial variability in drug response phenotypes among different populations Conclusion: The results of our study revealed significant genetic variation among Iranian populations that could significantly influence clinical decision-making. This study shows the frequency pattern of the effective variant of NUDT15 in determining the phenotype in Iranian population. © 2025 Elsevier B.V., All rights reserved.