Vancomycin Loaded Halloysite Nanotubes Embedded in Silk Fibroin Hydrogel Applicable for Bone Tissue Engineering

Vancomycin Loaded Halloysite Nanotubes Embedded in Silk Fibroin Hydrogel Applicable for Bone Tissue Engineering Publisher

Avani F¹ ; Damoogh S² ; Mottaghitalab F³ ; Karkhaneh A¹ ; Farokhi M²

Show Affiliations

1. Biomedical Engineering Faculty, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran
2. National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran
3. Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Polymeric Materials and Polymeric Biomaterials Published:2020

Abstract

Despite the progress in antibiotic treatment, it is still challenging to promote bone regeneration in the case of chronic bone infection. Here, we synthesized composite hydrogels containing silk fibroin/halloysite nanotubes loaded with vancomycin. The hydrogel possessed 79.32% porosity, acceptable cell attachment, and biocompatibility. The release kinetics of vancomycin from halloysite and halloysite embedded in hydrogel were 60% and 32.5% over 23 days, respectively. Disk diffusion also showed an appropriate antibacterial activity over 10 days. Alkaline phosphatase and Alizarin red staining proved osteoconductivity of the scaffold. Totally, the data showed that composite hydrogel can be considered for treatment of bone infection. © 2019, © 2019 Taylor & Francis Group, LLC.

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Style	Citing Format
MLA	Avani F, et al.. "Vancomycin Loaded Halloysite Nanotubes Embedded in Silk Fibroin Hydrogel Applicable for Bone Tissue Engineering." International Journal of Polymeric Materials and Polymeric Biomaterials, vol. 69, no. 1, 2020, pp. 32-43.
APA	Avani F, Damoogh S, Mottaghitalab F, Karkhaneh A, Farokhi M (2020). Vancomycin Loaded Halloysite Nanotubes Embedded in Silk Fibroin Hydrogel Applicable for Bone Tissue Engineering. International Journal of Polymeric Materials and Polymeric Biomaterials, 69(1), 32-43.
Chicago	Avani F, Damoogh S, Mottaghitalab F, Karkhaneh A, Farokhi M. "Vancomycin Loaded Halloysite Nanotubes Embedded in Silk Fibroin Hydrogel Applicable for Bone Tissue Engineering." International Journal of Polymeric Materials and Polymeric Biomaterials 69, no. 1 (2020): 32-43.
Harvard	Avani F et al. (2020) 'Vancomycin Loaded Halloysite Nanotubes Embedded in Silk Fibroin Hydrogel Applicable for Bone Tissue Engineering', International Journal of Polymeric Materials and Polymeric Biomaterials, 69(1), pp. 32-43.
Vancouver	Avani F, Damoogh S, Mottaghitalab F, Karkhaneh A, Farokhi M. Vancomycin Loaded Halloysite Nanotubes Embedded in Silk Fibroin Hydrogel Applicable for Bone Tissue Engineering. International Journal of Polymeric Materials and Polymeric Biomaterials. 2020;69(1):32-43.
BibTex	@article{ author = {Avani F and Damoogh S and Mottaghitalab F and Karkhaneh A and Farokhi M}, title = {Vancomycin Loaded Halloysite Nanotubes Embedded in Silk Fibroin Hydrogel Applicable for Bone Tissue Engineering}, journal = {International Journal of Polymeric Materials and Polymeric Biomaterials}, volume = {69}, number = {1}, pages = {32-43}, year = {2020} }
RIS	TY - JOUR AU - Avani F AU - Damoogh S AU - Mottaghitalab F AU - Karkhaneh A AU - Farokhi M TI - Vancomycin Loaded Halloysite Nanotubes Embedded in Silk Fibroin Hydrogel Applicable for Bone Tissue Engineering JO - International Journal of Polymeric Materials and Polymeric Biomaterials VL - 69 IS - 1 SP - 32 EP - 43 PY - 2020 ER -

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