Application of Mesenchymal Stem Cells (Mscs) in Neurodegenerative Disorders: History, Findings, and Prospective Challenges Publisher Pubmed



Biglari N^{1, 2} ; Mehdizadeh A³ ; Vafaei Mastanabad M⁴ ; Gharaeikhezri MH⁵ ; Gol Mohammad Pour Afrakoti L⁶ ; Pourbala H⁷ ; Yousefi M^{2, 8} ; Soltanizangbar MS^{2, 8} Show Affiliations
Source: Pathology Research and Practice Published:2023

Abstract

Over the past few decades, the application of mesenchymal stem cells has captured the attention of researchers and practitioners worldwide. These cells can be obtained from practically every tissue in the body and are used to treat a broad variety of conditions, most notably neurological diseases such as Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, and Alzheimer's disease. Studies are still being conducted, and the results of these studies have led to the identification of several different molecular pathways involved in the neuroglial speciation process. These molecular systems are closely regulated and interconnected due to the coordinated efforts of many components that make up the machinery responsible for cell signaling. Within the scope of this study, we compared and contrasted the numerous mesenchymal cell sources and their cellular features. These many sources of mesenchymal cells included adipocyte cells, fetal umbilical cord tissue, and bone marrow. In addition, we investigated whether these cells can potentially treat and modify neurodegenerative illnesses. © 2023 Elsevier GmbH