Increased Expression of Cd44 Is Associated With More Aggressive Behavior in Clear Cell Renal Cell Carcinoma

Increased Expression of Cd44 Is Associated With More Aggressive Behavior in Clear Cell Renal Cell Carcinoma Publisher Pubmed

Zanjani LS¹ ; Madjd Z^{1, 2} ; Abolhasani M^{1, 3} ; Rasti A¹ ; Fodstad O^{4, 5} ; Andersson Y⁴ ; Asgari M^{1, 3}

Source: Biomarkers in Medicine Published:2018

Abstract

Aim: Although CD44 has been suggested as a prognostic marker in renal cell carcinoma (RCC), the prognostic significance of this marker in three main subtypes of RCC is still unclear. Thus, the present study was conducted to evaluate the expression and prognostic significance of CD44 as a cancer stem cell marker in different histological subtypes of RCC. Methodology & results: CD44 expression was evaluated in 206 well-defined renal tumor samples using immunohistochemistry on tissue microarrays. Higher CD44 expression was associated with more aggressive behavior, tumor progression and worse prognosis in clear cell RCC (ccRCC) but not in papillary and chromophobe RCC subtypes. Discussion & conclusion: Cancer stem cell marker CD44 may be a promising target for cancer treatment only in ccRCC. © 2018 Future Medicine Ltd.

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Style	Citing Format
MLA	Zanjani LS, et al.. "Increased Expression of Cd44 Is Associated With More Aggressive Behavior in Clear Cell Renal Cell Carcinoma." Biomarkers in Medicine, vol. 12, no. 1, 2018, pp. 45-61.
APA	Zanjani LS, Madjd Z, Abolhasani M, Rasti A, Fodstad O, Andersson Y, Asgari M (2018). Increased Expression of Cd44 Is Associated With More Aggressive Behavior in Clear Cell Renal Cell Carcinoma. Biomarkers in Medicine, 12(1), 45-61.
Chicago	Zanjani LS, Madjd Z, Abolhasani M, Rasti A, Fodstad O, Andersson Y, Asgari M. "Increased Expression of Cd44 Is Associated With More Aggressive Behavior in Clear Cell Renal Cell Carcinoma." Biomarkers in Medicine 12, no. 1 (2018): 45-61.
Harvard	Zanjani LS et al. (2018) 'Increased Expression of Cd44 Is Associated With More Aggressive Behavior in Clear Cell Renal Cell Carcinoma', Biomarkers in Medicine, 12(1), pp. 45-61.
Vancouver	Zanjani LS, Madjd Z, Abolhasani M, Rasti A, Fodstad O, Andersson Y, et al.. Increased Expression of Cd44 Is Associated With More Aggressive Behavior in Clear Cell Renal Cell Carcinoma. Biomarkers in Medicine. 2018;12(1):45-61.
BibTex	@article{ author = {Zanjani LS and Madjd Z and Abolhasani M and Rasti A and Fodstad O and Andersson Y and Asgari M}, title = {Increased Expression of Cd44 Is Associated With More Aggressive Behavior in Clear Cell Renal Cell Carcinoma}, journal = {Biomarkers in Medicine}, volume = {12}, number = {1}, pages = {45-61}, year = {2018} }
RIS	TY - JOUR AU - Zanjani LS AU - Madjd Z AU - Abolhasani M AU - Rasti A AU - Fodstad O AU - Andersson Y AU - Asgari M TI - Increased Expression of Cd44 Is Associated With More Aggressive Behavior in Clear Cell Renal Cell Carcinoma JO - Biomarkers in Medicine VL - 12 IS - 1 SP - 45 EP - 61 PY - 2018 ER -

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