Molecular Analysis of Occult Hepatitis B Infection Among Iranian Hiv-Positive Patients

Molecular Analysis of Occult Hepatitis B Infection Among Iranian Hiv-Positive Patients Publisher

Mohraz M¹ ; Jafari R² ; Poortahmasebi V² ; Sadeghi A² ; Hajabdolbaghi M¹ ; Rasoolinejad M¹ ; Forooghi M¹ ; Norouzi M² ; Poorebrahim M³ ; Khamseh A² ; Karkhaneh M² ; Alavian SM⁴ ; Ebrahimian A² ; Jazayeri SM¹

Show Affiliations

1. Iranian Research Center for HIV AIDS, High Risk Reduction Institute, Tehran, Iran
2. Hepatitis B Molecular Laboratory, Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
4. Middle East Liver Disease (MELD) Center, No 178, Sepahboud Gharanee St., Tehran, 1598976516, Iran

Source: Future Virology Published:2016

Abstract

Aim: The aims of this study were to find out the prevalence of occult hepatitis B infection (OBI) in HIV-1 patients, as well as to analyze the mutational patterns of OBI-positive individuals. Materials & methods: 172 HBsAg-negative, HIV-1-positive patients were selected according to data extracted from questionnaires. HBV serologic and molecular assays were performed. An extensive mutational analysis was applied using direct sequencing on HBsAg. Results: Thirty-one samples (18%) were OBI positive. Among 24 available OBI-positive samples, 17 (71%) contained at least one mutation only within 'a' determinant region of HBsAg. A stretch of mutations was found between amino acid positions 121 and 136. The physicochemical properties of individual amino acid substitutions and their potential impacts on 3D structure of 'a' determinant mutants were also determined. Conclusion: HBV serologic assays are not reliable markers to exclude occult HBV infection in HIV-positive patients. © 2016 Future Medicine Ltd.

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Style	Citing Format
MLA	Mohraz M, et al.. "Molecular Analysis of Occult Hepatitis B Infection Among Iranian Hiv-Positive Patients." Future Virology, vol. 11, no. 7, 2016, pp. 497-508.
APA	Mohraz M, Jafari R, Poortahmasebi V, Sadeghi A, Hajabdolbaghi M, Rasoolinejad M, Forooghi M, Norouzi M, Poorebrahim M, Khamseh A, Karkhaneh M, Alavian SM, Ebrahimian A, Jazayeri SM (2016). Molecular Analysis of Occult Hepatitis B Infection Among Iranian Hiv-Positive Patients. Future Virology, 11(7), 497-508.
Chicago	Mohraz M, Jafari R, Poortahmasebi V, Sadeghi A, Hajabdolbaghi M, Rasoolinejad M, Forooghi M, et al.. "Molecular Analysis of Occult Hepatitis B Infection Among Iranian Hiv-Positive Patients." Future Virology 11, no. 7 (2016): 497-508.
Harvard	Mohraz M et al. (2016) 'Molecular Analysis of Occult Hepatitis B Infection Among Iranian Hiv-Positive Patients', Future Virology, 11(7), pp. 497-508.
Vancouver	Mohraz M, Jafari R, Poortahmasebi V, Sadeghi A, Hajabdolbaghi M, Rasoolinejad M, et al.. Molecular Analysis of Occult Hepatitis B Infection Among Iranian Hiv-Positive Patients. Future Virology. 2016;11(7):497-508.
BibTex	@article{ author = {Mohraz M and Jafari R and Poortahmasebi V and Sadeghi A and Hajabdolbaghi M and Rasoolinejad M and Forooghi M and Norouzi M and Poorebrahim M and Khamseh A and Karkhaneh M and Alavian SM and Ebrahimian A and Jazayeri SM}, title = {Molecular Analysis of Occult Hepatitis B Infection Among Iranian Hiv-Positive Patients}, journal = {Future Virology}, volume = {11}, number = {7}, pages = {497-508}, year = {2016} }
RIS	TY - JOUR AU - Mohraz M AU - Jafari R AU - Poortahmasebi V AU - Sadeghi A AU - Hajabdolbaghi M AU - Rasoolinejad M AU - Forooghi M AU - Norouzi M AU - Poorebrahim M AU - Khamseh A AU - Karkhaneh M AU - Alavian SM AU - Ebrahimian A AU - Jazayeri SM TI - Molecular Analysis of Occult Hepatitis B Infection Among Iranian Hiv-Positive Patients JO - Future Virology VL - 11 IS - 7 SP - 497 EP - 508 PY - 2016 ER -

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