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Research Trends in Car-T Cell Therapy a Comprehensive Bibliometric Analysis Highlighting Cardiovascular Toxicity and Clinical Implications Publisher Pubmed



Ameen D1 ; Aminisalehi E2 ; Nayak SS1 ; Ahmed A1 ; Pudimat A3 ; Nasrollahizadeh A4 ; Hosseini K4 ; Hosseini Jebelli SF5 ; Asl AA5 ; Nguyen AL6
Authors
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Authors Affiliations
  1. 1. Department of Internal Medicine, Yale New Haven Health Bridgeport Hospital, Bridgeport, CT, United States
  2. 2. School of Medicine, Guilan University of Medical Science, Rasht, Iran
  3. 3. University of Bridgeport, Bridgeport, CT, United States
  4. 4. Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Cardio-Oncology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Science, Tehran, Iran
  6. 6. Division of Hematology/Oncology, Department of Internal Medicine, UC San Diego Health Moores Cancer Center, San Diego, CA, United States

Source: Medicine (United States) Published:2025


Abstract

Background: Chimeric antigen receptor T cell (CAR-T) therapy is an innovation in oncology, which provides targeted treatment alternatives for certain tumors. CAR-T therapy has been associated to adverse cardiovascular consequences despite its potential for therapeutic benefit. As research in this field expands rapidly, a bibliometric study is needed to map the current state of knowledge and highlight emerging areas of interest to guide future studies and optimize patient outcomes. Methods: A comprehensive bibliometric analysis was conducted using the Web of Science Core Collection and PubMed to examine the literature on CAR-T cell therapy and its cardiovascular implications. Results: The annual number of publications on CAR-T therapy and cardiovascular symptoms has steadily increased, experiencing a significant surge starting in 2018. The USA, China, and Germany emerged as the leading contributors. Key journals included Frontiers in Immunology and Blood, while highly cited journals were Lancet Oncology and the Journal of Clinical Oncology. Keyword analysis identified multiple myeloma, immunotherapy, and cytokine release syndrome as major research themes. The clustered map highlighted interconnected research areas, with a significant focus on multiple myeloma, combination therapy, cardiovascular magnetic resonance assessment, and novel therapeutic approaches. Conclusion: This bibliometric analysis provided a detailed overview of the research landscape on CAR-T cell therapy and its cardiovascular implications, identifying trends and gaps in knowledge. Recent research trends highlighted bispecific antibodies, CAR-T cell therapy, cardiovascular events, lymphoma, management, and outcomes as emerging focus areas. These keywords underscore the developing field of cardiac events, management, and outcomes in patients undergoing CAR-T cell therapy. Copyright © 2025 the Author(s).
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