Primary Cardiac Angiosarcoma With Pulmonary Metastasis in a Young Female: A Case Report

Summary: Can a heart tumor cause sudden rupture? A case report describes metastatic angiosarcoma and atrial rupture, showing diagnostic challenges. #Cardiology #Oncology

Kordjazy N ; Parkhideh R ; Naseri A S ; Foroumandi M ; Taheri P
Source: Iranian Heart Journal Published:2026

Abstract

Cardiac angiosarcoma is a rare and highly aggressive malignancy with nonspecific clinical manifestations, often leading to delayed diagnosis. In this article, we report a 38-year-old woman who presented with diarrhea, dry cough, and a history of blunt chest trauma 3 weeks prior to admission. Initial echocardiography revealed massive pericardial effusion complicated by cardiac tamponade. Further diagnostic evaluation, including cardiac computed tomographic angiography, demonstrated right atrial wall rupture. Intraoperative sampling of the pulmonary nodules and the ruptured atrial wall was performed, and histopathologic examination confirmed metastatic cardiac angiosarcoma. Despite surgical intervention, and given the advanced stage of the tumor, the oncology team recommended palliative care. The patient developed progressive right-sided heart failure and died after a 53-day stay in the intensive care unit. This case highlights the diagnostic challenges of cardiac angiosarcoma and underscores the importance of early recognition and stage-appropriate management to improve clinical outcomes. © 2026, Iranian Heart Association. All rights reserved.