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Evaluation of Some Plasma Coagulation Factors in Women With Spontaneous Miscarriage



Besharat M1 ; Tabandeh A2 ; Keshtkar A3 ; Mobasheri E4 ; Besharat S5 ; Joshaghani H6, 7
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Authors Affiliations
  1. 1. Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran
  2. 2. Golestan Research Center for Infertility, Golestan University of Medical Sciences, Gorgan, Iran
  3. 3. Endocrine and Metabolic Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Golestan Research Center of Congenital Abnormality, Golestan University of Medical Sciences, Gorgan, Iran
  5. 5. Tehran University of Medical Sciences, Digestive Disease Research Institute Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran
  6. 6. Medical Laboratory Research Center, Golestan University of Medical Sciences, Gorgan, Iran
  7. 7. Department of Medical Laboratory Technology, School of Paramedicine, Building of Falsafi, Hircan Boulevard, Gorgan, Iran

Source: International Journal of Fertility and Sterility Published:2015

Abstract

Background: It has been reported that 15-20% of parous female have experienced at least one miscarriage, while 3% of them have experienced two miscarriages. The goal of this study was to evaluate the plasma level of coagulation factors in women with a history of spontaneous abortions. Materials and Methods: In this case-control study, 82 women with a history of two or more abortions referred to the six private gynecologic clinics in Gorgan city without any structural abnormality were recruited during 2011-2012. Plasma levels of antithrombin III (ATIII) using colorimetric assay, protein C, protein S, factor V Leiden and lupus anticoagulant (LAC) using coagulation method were measured. The control group was women with a history of normal delivery and no abortions. Those under anti-coagulant therapy were excluded from the study. Data were entered into the computer using the Statistical Package for the Social Sciences (SPSS, SPSS Inc., Chicago, IL, USA) version 16 and analyzed by Chi-square, t test and non-parametric tests. Results: At least one abnormality was reported in 35 cases (42.7%). Among them, protein C deficiency was the most prevalent (30.5%). ATIII was abnormal in 17.1% and lupus anti-coagulant was abnormal in 8.5%. Factor V Leiden was normal in all cases and protein S deficiency was only seen in one case. Conclusion: We suggest to perform these tests in regards to the thrombophilia in cases with spontaneous abortions in order to find an early cure for this treatable disorder. © 2015, Royan Institute (ACECR). All rights reserved.
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