Cytotoxic Effect of Hydroalcoholic Extract of Cota Tinctoria (L.) J.Gay on Ags and Hep-G2 Cancer Cell Lines; [Efecto Citotoxico Del Extracto Hidroalcoholico De Cota Tinctoria (L.) J. Gay Sobre Lineas Celulares De Cancer Ags Y Hep-G2] Publisher



Shamloo S¹ ; Marandi SJ¹ ; Tajadod G¹ ; Majd A¹ ; Rahimi R² Show Affiliations
Source: Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Published:2022

Abstract

Cota tinctoria is a medicinal plant which has been used for management of cancer in folk medicine of various regions. The aim of present study is to investigate cytotoxic activity of different concentrations of hydroalcoholic extract of C. tinctoria flowers on gastric (AGS) and liver (Hep-G2) cancer cell lines as well as Human Natural GUM fibroblast (HUGU) cells. Cell mortality rates were examined after 24, 48 and 72 h incubations using the MTT assay. IC50 of extract on AGS cells after 24, 48 and 72h was 1.46, 1.29 and 1.14 µg/mL respectively. The extract demonstrated IC50 of 5.15, 3.92 and 2.89 µg/mL on Hep-G2 cells after 24, 48 and 72 h respectively. No cytotoxic effect was detected on HUGU (Human Natural GUM fibroblast) cells. C. tinctoria seems to have a promising potential to be considered as a source for anticancer drug discovery. However, more experimental and clinical studies are required. © / ISSN 0717 7917 / www.blacpma.ms-editions.cl.