Synthesis, Characterization and in Vitro Bioactivity of Mesoporous Copper Silicate Bioactive Glasses

Synthesis, Characterization and in Vitro Bioactivity of Mesoporous Copper Silicate Bioactive Glasses Publisher

Koohkan R¹ ; Hooshmand T¹ ; Tahriri M² ; Mohebbikalhori D³

Show Affiliations

1. Department of Dental Biomaterials, School of Dentistry/Research Center for Science and Technology in Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. School of Dentistry, Marquette University, Milwaukee, WI, United States
3. Chemical Engineering Department, Faculty of Engineering, University of Sistan and Baluchestan, Zahedan, Iran

Source: Ceramics International Published:2018

Abstract

In this study, 68SiO2–23CaO–4P2O5–CuO bioglasses with and without surfactant (nonionic block copolymer, EO20PO70EO20 P123) for producing multifunctional scaffold were synthesized by sol-gel method. The resulting dried sol underwent an evaporation-induced self-assembly (EISA) process at 40 °C. TG-DTA (thermogravimetric-differential thermal analysis) was completed to obtain the optimized temperature for calcination of the prepared powder. The dried gel was calcined at 650 °C for 2 h to obtain the final bioglasses. Then, the composition and phase structure, morphology, surface area and mesoporous structure were evaluated by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET) analyses. In addition, the biological behavior (bioactivity, biocompatibility and antibacterial properties) of the powder was examined for their applicability in medical science. The results demonstrated that the synthesized bioglass powder formed mesoporous structure with nano-sized morphology and high surface area, and also suitable biological characteristics. The P123 (the nonionic block copolymer EO20PO70EO20) surfactant was responsible for improving homogeneous mesoporous structures and biological characteristics for the template bioglass. In addition, the use of copper in the glass structure did not inhibit its anti-bacterial properties and resulted in a low risk toxic bioglass. Finally, this synthesized bioactive glass could have the potential capability for bone defects treatment in tissue engineering due to their versatile attributes. © 2017 Elsevier Ltd and Techna Group S.r.l.

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Experts (# of related papers)

Tabassom Hooshmand (1)

Nasrin Lotfibakhshaiesh (1)

Style	Citing Format
MLA	Koohkan R, et al.. "Synthesis, Characterization and in Vitro Bioactivity of Mesoporous Copper Silicate Bioactive Glasses." Ceramics International, vol. 44, no. 2, 2018, pp. 2390-2399.
APA	Koohkan R, Hooshmand T, Tahriri M, Mohebbikalhori D (2018). Synthesis, Characterization and in Vitro Bioactivity of Mesoporous Copper Silicate Bioactive Glasses. Ceramics International, 44(2), 2390-2399.
Chicago	Koohkan R, Hooshmand T, Tahriri M, Mohebbikalhori D. "Synthesis, Characterization and in Vitro Bioactivity of Mesoporous Copper Silicate Bioactive Glasses." Ceramics International 44, no. 2 (2018): 2390-2399.
Harvard	Koohkan R et al. (2018) 'Synthesis, Characterization and in Vitro Bioactivity of Mesoporous Copper Silicate Bioactive Glasses', Ceramics International, 44(2), pp. 2390-2399.
Vancouver	Koohkan R, Hooshmand T, Tahriri M, Mohebbikalhori D. Synthesis, Characterization and in Vitro Bioactivity of Mesoporous Copper Silicate Bioactive Glasses. Ceramics International. 2018;44(2):2390-2399.
BibTex	@article{ author = {Koohkan R and Hooshmand T and Tahriri M and Mohebbikalhori D}, title = {Synthesis, Characterization and in Vitro Bioactivity of Mesoporous Copper Silicate Bioactive Glasses}, journal = {Ceramics International}, volume = {44}, number = {2}, pages = {2390-2399}, year = {2018} }
RIS	TY - JOUR AU - Koohkan R AU - Hooshmand T AU - Tahriri M AU - Mohebbikalhori D TI - Synthesis, Characterization and in Vitro Bioactivity of Mesoporous Copper Silicate Bioactive Glasses JO - Ceramics International VL - 44 IS - 2 SP - 2390 EP - 2399 PY - 2018 ER -

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