The Effect of Berberine Supplementation on Obesity Indices: A Dose– Response Meta-Analysis and Systematic Review of Randomized Controlled Trials

The Effect of Berberine Supplementation on Obesity Indices: A Dose– Response Meta-Analysis and Systematic Review of Randomized Controlled Trials Publisher Pubmed

Xiong P¹ ; Niu L² ; Talaei S³ ; Kordvarkaneh H⁴ ; Clark CCT⁵ ; Gaman MA⁶ ; Rahmani J⁴ ; Dorosti M⁷ ; Mousavi SM⁸ ; Zarezadeh M⁹ ; Taghizadebilondi H⁴ ; Zhang J¹⁰

Show Affiliations

1. Department of Cardiovasology, The Second People's Hospital of Liaocheng, Linqing, 252600, Shandong Province, China
2. Department of Cadre Health Care, Qingdao Municipal Hospital, Qingdao, 266011, Shandong Province, China
3. School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Student Research Committee, Department of Clinical Nutrition and Dietetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5. Centre for Sport, Exercise, and Life Sciences, Coventry University, Coventry, CV15FB, United Kingdom
6. Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., Bucharest, 050474, Romania
7. Student Research Committee, Department of Nutrition, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
8. Department of Community Nutrition, Studentsâ€™ Scientific Research Center (SSRC), School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran
9. Department of Clinical Nutrition, Student Research Committee, Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
10. Department of Cardiology, Qingdao Hiser Medical Center, No.4, People's Road, Sifang District, Qingdao, 266033, Shandong Province, China

Source: Complementary Therapies in Clinical Practice Published:2020

Abstract

Background: and purpose: Clinical studies investigating the effects of berberine supplementation on anthropometric indices in humans have generated inconsistent results. Thus, the objective of this systematic review and meta-analysis was to clarify the effects of berberine supplementation on obesity indices in human subjects. Methods: Several online medical databases were systematically searched up to February 2019. All clinical trials exploring the effects of berberine supplementation on indices of obesity were included. The combined weighted mean difference (WMD) of eligible studies was assessed using a random-effects model. We evaluated publication bias by using the Egger's test. Results: Overall, 10 studies were included. The combined outcomes suggested a significant influence of berberine administration on body mass index (BMI) (WMD: −0.29 kg/m2, 95% CI: −0.51 to −0.08, p = 0.006) and waist circumference (WC) (WMD: −2.75 cm, 95% CI: −4.88 to −0.62, p = 0.01). However, berberine supplementation yielded no significant decline in body weight (BW) (WMD: −0.11 kg, 95% CI: −0.99 to 0.76, p = 0.79). Following the dose-response evaluation, berberine intake was found to significantly reduce BMI (r = −0.02) and WC (r = −0.72) based on treatment duration. Conclusion: The results of the current study support the use of berberine supplementation for the improvement of obesity indices. © 2020

Related Docs

View other Related Docs

1. The Effects of Berberine Supplementation on Cardiovascular Risk Factors in Adults: A Systematic Review and Dose-Response Meta-Analysis, Frontiers in Nutrition (2022)

2. Effects of Berberine and Barberry on Anthropometric Measures: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Complementary Therapies in Medicine (2020)

3. Plant-Derived Natural Agents As Dietary Supplements for the Regulation of Glycosylated Hemoglobin: A Review of Clinical Trials, Clinical Nutrition (2020)

4. Berberine-Induced Glucagon-Like Peptide-1 and Its Mechanism for Controlling Type 2 Diabetes Mellitus: A Comprehensive Pathway Review, Archives of Physiology and Biochemistry (2023)

5. Effects Berberine–Silymarin on Liver Enzymes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Clinical Nutrition ESPEN (2022)

6. The Effect of L-Carnitine Supplementation on Serum Leptin Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Endocrine (2018)

7. The Effect of Berberine Supplementation on Glycemic Control and Inflammatory Biomarkers in Metabolic Disorders: An Umbrella Meta-Analysis of Randomized Controlled Trials, Clinical Therapeutics (2024)

8. Elevated Neopterin in Tuberculosis and Co-Infection With Hiv and the Effect of Treatment: A Systematic Review, Meta-Analysis, and Meta-Regression, International Immunopharmacology (2022)

Experts (# of related papers)

View all Related Experts

Sakineh Shab-Bidar (20)

Hamed Mohammadi (9)

Style	Citing Format
MLA	Xiong P, et al.. "The Effect of Berberine Supplementation on Obesity Indices: A Dose– Response Meta-Analysis and Systematic Review of Randomized Controlled Trials." Complementary Therapies in Clinical Practice, vol. 39, no. , 2020, pp. -.
APA	Xiong P, Niu L, Talaei S, Kordvarkaneh H, Clark CCT, Gaman MA, Rahmani J, Dorosti M, Mousavi SM, Zarezadeh M, Taghizadebilondi H, Zhang J (2020). The Effect of Berberine Supplementation on Obesity Indices: A Dose– Response Meta-Analysis and Systematic Review of Randomized Controlled Trials. Complementary Therapies in Clinical Practice, 39(), -.
Chicago	Xiong P, Niu L, Talaei S, Kordvarkaneh H, Clark CCT, Gaman MA, Rahmani J, et al.. "The Effect of Berberine Supplementation on Obesity Indices: A Dose– Response Meta-Analysis and Systematic Review of Randomized Controlled Trials." Complementary Therapies in Clinical Practice 39, no. (2020): -.
Harvard	Xiong P et al. (2020) 'The Effect of Berberine Supplementation on Obesity Indices: A Dose– Response Meta-Analysis and Systematic Review of Randomized Controlled Trials', Complementary Therapies in Clinical Practice, 39(), pp. -.
Vancouver	Xiong P, Niu L, Talaei S, Kordvarkaneh H, Clark CCT, Gaman MA, et al.. The Effect of Berberine Supplementation on Obesity Indices: A Dose– Response Meta-Analysis and Systematic Review of Randomized Controlled Trials. Complementary Therapies in Clinical Practice. 2020;39():-.
BibTex	@article{ author = {Xiong P and Niu L and Talaei S and Kordvarkaneh H and Clark CCT and Gaman MA and Rahmani J and Dorosti M and Mousavi SM and Zarezadeh M and Taghizadebilondi H and Zhang J}, title = {The Effect of Berberine Supplementation on Obesity Indices: A Dose– Response Meta-Analysis and Systematic Review of Randomized Controlled Trials}, journal = {Complementary Therapies in Clinical Practice}, volume = {39}, number = {}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Xiong P AU - Niu L AU - Talaei S AU - Kordvarkaneh H AU - Clark CCT AU - Gaman MA AU - Rahmani J AU - Dorosti M AU - Mousavi SM AU - Zarezadeh M AU - Taghizadebilondi H AU - Zhang J TI - The Effect of Berberine Supplementation on Obesity Indices: A Dose– Response Meta-Analysis and Systematic Review of Randomized Controlled Trials JO - Complementary Therapies in Clinical Practice VL - 39 IS - SP - EP - PY - 2020 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract