Tehran University of Medical Sciences

Science Communicator Platform

Share By
The Association of Microrna-145 and Microrna-191 With Therapeutic Response in Patients With Inflammatory Bowel Disease Publisher



Savas O A ; Acik H ; Kivilcim T ; Akbari A M ; Sheikhvatan M
Authors

Source: Journal of Clinical Medicine Published:2026


Abstract

Background: The discovery of non-invasive biomarkers that can predict the therapeutic response in Inflammatory Bowel Disease (IBD) is of utmost importance in the field of personalized medicine. The present prospective cohort study was designed to investigate the use of circulating levels of plasma microRNA-145 (miR-145) and microRNA-191 (miR-191) in the diagnosis and association with therapeutic response in Crohn’s disease (CD) and ulcerative colitis (UC). Methods: The present study was conducted as a retrospective observational cohort study on 183 adult IBD patients, consisting of 96 CD patients and 87 UC patients. Patient data and study parameters were obtained retrospectively from existing clinical records and available laboratory/molecular data collected during routine clinical care. A healthy control group consisting of 92 individuals was included for comparison with the patients with IBD. The circulating levels of miR-145 and miR-191 were assessed in the peripheral blood plasma at baseline using qRT PCR. The clinical response was evaluated at 12 weeks using the CDAI score for CD and the Mayo score for UC. Results: In active IBD, there was significant down-regulation of miR-145 and significant up-regulation of miR-191. Responders at 12 weeks had significantly higher levels of baseline miR-145 (2.0-fold, p < 0.001) and lower levels of miR-191 (1.8-fold, p < 0.001) compared with non-responders. Also, miR-145 negatively correlated with disease activity, and miR-191 positively correlated with acute inflammation markers. ROC curve analysis showed good discriminative values for both miR-145 and miR-191. Conclusions: The level of circulating miR-145 and miR-191 correlates with the activity of IBD. Importantly, the baseline level of miR-145 expression is a non-invasive potential biomarker associated with therapeutic response at 12 weeks. © 2026 by the authors.
Related Docs
View other Related Docs
1. The Rs2910164 Variant Is Associated With Reduced Mir-146A Expression But Not Cytokine Levels in Patients With Type 2 Diabetes, Journal of Endocrinological Investigation (2018)
2. Differential Expression of Circulating Mir-21, Mir-142-3P and Mir-155 in Renal Transplant Recipients With Impaired Graft Function, International Urology and Nephrology (2017)
3. Downregulated Microrna-155 Expression in Peripheral Blood Mononuclear Cells of Type 2 Diabetic Patients Is Not Correlated With Increased Inflammatory Cytokine Production, Cytokine (2015)
Experts (# of related papers)
View all Related Experts
Reza Meshkani (4)
Farideh Razi (3)
Other Related Docs
4. Evaluation of Mir-122 Level in the Plasma of Chronically Hcv Infected Patients, Molekuliarnaia biologiia (2016)
5. Evaluation of Mir-122 Level in the Plasma of Chronically Hcv Infected Patients, Molecular Biology (2016)
6. Evaluation of Mir-155 Expression in Peripheral Blood Samples of Copd Patients, Journal of Craniomaxillofacial Research (2025)
7. Decreased Serum Level of Mir-155 Is Associated With Obesity and Its Related Metabolic Traits, Clinical Laboratory (2018)
8. Reproducible and Reliable Real-Time Pcr Assay to Measure Mature Form of Mir-141, Applied Immunohistochemistry and Molecular Morphology (2016)
9. Decreased Serum Microrna-21 Level Is Associated With Obesity in Healthy and Type 2 Diabetic Subjects, Archives of Physiology and Biochemistry (2018)
10. Evaluation of Microrna Expression Pattern (Mir-28, Mir-181A, Mir-34A, and Mir-31) in Patients With Covid-19 Admitted to Icu and Diabetic Covid-19 Patients, Intervirology (2023)
11. The Effects of All Trans Retinoic Acid, Vitamin D3 and Their Combination on Plasma Levels of Mirna-125A-5P, Mirna-34A, and Mirna-126 in an Experimental Model of Diabetes, Avicenna Journal of Phytomedicine (2022)
12. Expression of Circulatory Microrna-155 in Non-Hodgkin Lymphomas and Rheumatoid Arthritis, Medical Journal of Tabriz University of Medical Sciences (2022)
13. Expression of Microrna-155 in Patients With Non-Hodgkin Lymphoma, Coronavirus Disease 2019, or Both: A Cross-Sectional Study, Iranian Journal of Medical Sciences (2023)
14. Circulating Levels of the Mirnas, Mir-194, and Mir-29B, As Clinically Useful Biomarkers for Colorectal Cancer, Tumor Biology (2016)
15. A Comprehensive Review on Mir-146A Molecular Mechanisms in a Wide Spectrum of Immune and Non-Immune Inflammatory Diseases, Immunology Letters (2020)
16. Over Expression of Circulating Mir-155 Predicts Prognosis in Diffuse Large B-Cell Lymphoma, Leukemia Research (2018)
17. Downregulation of Mir-148B As Biomarker for Early Detection of Hepatocellular Carcinoma and May Serve As a Prognostic Marker, Tumor Biology (2016)
18. Real-Time Pcr Technique for Diagnosing Respiratory Diseases: Mir-155, Mir-17, Mir-181 Expression, and Copd, Egyptian Journal of Bronchology (2025)
19. Exploring Plasma Expression Levels of Mir-200C-3P, Mir-150, and Mir-155 in Sars-Cov-2 Positive and Negative Subjects, Future Virology (2024)
20. The Role of Inflammatory Mirna–Mrna Interactions in Pbmcs of Colorectal Cancer and Obesity Patients, Immunity# Inflammation and Disease (2022)