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Potentially Effective Natural Drugs in Treatment for the Most Common Rheumatic Disorder: Osteoarthritis Publisher Pubmed



Farzaei MH1, 2 ; Farzaei F3 ; Gooshe M5 ; Abbasabadi Z2 ; Rezaei N6, 7, 8, 9 ; Abdolghaffari AH10, 11
Authors
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Authors Affiliations
  1. 1. Department of Traditional Pharmacy, Tehran University of Medical Sciences, Tehran, 1417653761, Iran
  2. 2. Kermanshah University of Medical Sciences, Kermanshah, 6734667149, Iran
  3. 3. College of Veterinary Medicine, Kermanshah Razi University, Kermanshah, 6715685414, Iran
  4. 4. Tehran University of Medical Sciences, Tehran, 1417614411, Iran
  5. 5. Students’ Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, 1417614411, Iran
  6. 6. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Department of Infection and Immunity, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, United Kingdom
  10. 10. Pharmacology and Applied Medicine Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj-Qazvin Freeway, Supa, Boulevard, Jahade-Daneshgahi Research Society, P.O Box: 141554364, Karaj, Alborz, Iran
  11. 11. International Campus, Tehran University of Medical Sciences (ICTUMS), Tehran, 1417653861, Iran

Source: Rheumatology International Published:2015


Abstract

Osteoarthritis (OA) is a chronic condition in which imbalance between anabolic and catabolic mediators occurs leading to the destruction of homeostasis of articular cartilage. The current drugs in the management of OA can just alleviate symptoms. Hence, the research tendency toward exploration of novel sources has been grown up in order to achieve safe and efficacious drugs. Meanwhile, various components exist as novel natural drugs that may possess favorable properties for the management of OA. This review focuses on the most efficacious medicinal plants and their phytochemical agents, which have been consumed for the management of OA. Moreover, evaluation of their efficacy and molecular mechanisms of action are discussed based on numerous modern experimental investigations. More research is needed to develop therapeutic agents with disease-modifying properties to treat OA. © 2014, Springer-Verlag Berlin Heidelberg.