Tehran University of Medical Sciences

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Contribution of Long Noncoding Rna Hotair Variants to Preeclampsia Susceptibility in Iranian Women Publisher Pubmed



Esmkhani S1 ; Sadeghi H2 ; Ghasemian M3 ; Pirjani R4 ; Aminbeidokhti M5 ; Gholami M6 ; Yassaee F7 ; Mirfakhraie R5
Authors

Source: Hypertension in Pregnancy Published:2021


Abstract

Objective: To investigate the possible association of lncRNA HOTAIR rs920778 and rs874945 polymorphisms with preeclampsia risk in a sample from the Iranian population. Method: The study subjects included 250 preeclamptic women and 250 healthy women. The genotyping for rs920778 and rs874945 polymorphisms were performed using the TP-ARMS-PCR method. Results: HOTAIR rs920778 increased the risk of preeclampsia under the dominant and recessive inheritance patterns (OR = 4.84, 95% CI: 3.30–7.10, P < 0.0001; OR = 6.86, 95% CI: 3.51–13.42, P < 0.0001; respectively). Conclusion: This study confirmed the association of HOTAIR rs920778 polymorphism with preeclampsia in Iranian women. Further studies should be performed to confirm our findings. © 2020 Informa UK Limited, trading as Taylor & Francis Group.