A Candidate Intronic Cyp24a1 Gene Variant Affects the Risk of Colorectal Cancer

A Candidate Intronic Cyp24a1 Gene Variant Affects the Risk of Colorectal Cancer Publisher Pubmed

Sadeghi H^{1, 2, 3} ; Nazemalhosseinimojarad E² ; Piltan S¹ ; Fazeli E¹ ; Moradi Y⁴ ; Aminbeidokhti M¹ ; Yassaee VR³ ; Aghdaei HA⁵ ; Zali MR² ; Mirfakhraie R^{1, 3}

Show Affiliations

1. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Department of Gastrointestinal Cancer, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Molecular Genetics Department, Genomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5. Department of Molecular Biology, Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Biomarkers in Medicine Published:2019

Abstract

Aim: rs2585428 and rs4809960 polymorphisms were significantly associated with overall cancer risk, but there is no evidence regarding the overall colorectal cancer (CRC) risk. Materials & methods: A total of 505 subjects, including 246 patients with CRC and 259 noncancer controls participated in the study. The genotyping was performed using tetra-primer amplification refractory mutation systems PCR. Results: Analysis of genotypes revealed that CYP24A1 rs4809960 CC genotype decreased the risk of CRC (p = 0.009). In addition, the genotype frequencies showed a significant difference under the dominant and recessive inheritance models (p = 0.019 and p = 0.02, respectively). Conclusion: Our findings indicate that the CYP24A1 rs4809960 polymorphism decreased the risk of CRC in the studied population. © 2019 Future Medicine Ltd.

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Style	Citing Format
MLA	Sadeghi H, et al.. "A Candidate Intronic Cyp24a1 Gene Variant Affects the Risk of Colorectal Cancer." Biomarkers in Medicine, vol. 14, no. 1, 2019, pp. 23-29.
APA	Sadeghi H, Nazemalhosseinimojarad E, Piltan S, Fazeli E, Moradi Y, Aminbeidokhti M, Yassaee VR, Aghdaei HA, Zali MR, Mirfakhraie R (2019). A Candidate Intronic Cyp24a1 Gene Variant Affects the Risk of Colorectal Cancer. Biomarkers in Medicine, 14(1), 23-29.
Chicago	Sadeghi H, Nazemalhosseinimojarad E, Piltan S, Fazeli E, Moradi Y, Aminbeidokhti M, Yassaee VR, Aghdaei HA, Zali MR, Mirfakhraie R. "A Candidate Intronic Cyp24a1 Gene Variant Affects the Risk of Colorectal Cancer." Biomarkers in Medicine 14, no. 1 (2019): 23-29.
Harvard	Sadeghi H et al. (2019) 'A Candidate Intronic Cyp24a1 Gene Variant Affects the Risk of Colorectal Cancer', Biomarkers in Medicine, 14(1), pp. 23-29.
Vancouver	Sadeghi H, Nazemalhosseinimojarad E, Piltan S, Fazeli E, Moradi Y, Aminbeidokhti M, et al.. A Candidate Intronic Cyp24a1 Gene Variant Affects the Risk of Colorectal Cancer. Biomarkers in Medicine. 2019;14(1):23-29.
BibTex	@article{ author = {Sadeghi H and Nazemalhosseinimojarad E and Piltan S and Fazeli E and Moradi Y and Aminbeidokhti M and Yassaee VR and Aghdaei HA and Zali MR and Mirfakhraie R}, title = {A Candidate Intronic Cyp24a1 Gene Variant Affects the Risk of Colorectal Cancer}, journal = {Biomarkers in Medicine}, volume = {14}, number = {1}, pages = {23-29}, year = {2019} }
RIS	TY - JOUR AU - Sadeghi H AU - Nazemalhosseinimojarad E AU - Piltan S AU - Fazeli E AU - Moradi Y AU - Aminbeidokhti M AU - Yassaee VR AU - Aghdaei HA AU - Zali MR AU - Mirfakhraie R TI - A Candidate Intronic Cyp24a1 Gene Variant Affects the Risk of Colorectal Cancer JO - Biomarkers in Medicine VL - 14 IS - 1 SP - 23 EP - 29 PY - 2019 ER -

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