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Long-Term Vaccine Delivery and Immunological Responses Using Biodegradable Polymer-Based Carriers Publisher Pubmed



Malekkhatabi A1 ; Tabandeh Z2 ; Nouri A3 ; Mozayan E4 ; Sartorius R5 ; Rahimi S3 ; Jamaledin R6
Authors
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Authors Affiliations
  1. 1. Department of Pharmaceutical Biomaterials, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 1417614411, Iran
  2. 2. Department of Physical Chemistry, Faculty of Chemistry, University of Kashan, Kashan, 8731753153, Iran
  3. 3. School of Chemistry, College of Science, University of Tehran, Tehran, 141556455, Iran
  4. 4. Department of Cell and Molecular Biology, University of Kashan, Kashan, 8731753153, Iran
  5. 5. Institute of Biochemistry and Cell Biology (IBBC), Naples, 80131, Italy
  6. 6. Department of Chemical, Materials & Industrial Production Engineering, University of Naples Federico II, Naples, 80125, Italy

Source: ACS Applied Bio Materials Published:2022


Abstract

Biodegradable polymers are largely employed in the biomedical field, ranging from tissue regeneration to drug/vaccine delivery. The biodegradable polymers are highly biocompatible and possess negligible toxicity. In addition, biomaterial-based vaccines possess adjuvant properties, thereby enhancing immune responses. This Review introduces the use of different biodegradable polymers and their degradation mechanism. Different kinds of vaccines, as well as the interaction between the carriers with the immune system, then are highlighted. Natural and synthetic biodegradable micro-/nanoplatforms, hydrogels, and scaffolds for local or targeted and controlled vaccine release are subsequently discussed. © 2022 American Chemical Society. All rights reserved.
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