French Maritime Pine Bark Extract and Neurological Disorders Publisher



Norouzy A¹ ; Malekahmadi M² Show Affiliations
Source: Treatments# Nutraceuticals# Supplements# and Herbal Medicine in Neurological Disorders Published:2023

Abstract

French maritime pine bark extract that contains catechin, taxifolin and a range of phenolic acids in addition to procyanidine is a powerful antioxidant. Based on the antiinflammatory properties of French maritime pine bark extract in many clinical studies as well as the neuroprotective effects observed in the animal model of Traumatic brain injury (TBI), we aimed to evaluate the effects of it on inflammatory, clinical, and nutritional status in TBI patients for the first time. TBI is one of leading causes of death due to trauma. Many studies have shown that cytokines, chemokines, and growth factors play important roles in the pathophysiology of TBI. On the other hand, many patients admitted to the intensive care unit face the problem of malnutrition, which is directly related to the state of inflammation. In Parkinson's disease (PD), French maritime pine bark significantly increased cell viability and decreased dose-dependent PC12 cell apoptosis. French maritime bark pine significantly inhibited inducible nitric oxide synthase-nitric oxide signaling in PC12 cells and nuclear factor-κB (NF-κB) activation. These findings suggested the protective effect of pycnogenol in PD. In Alzheimer's disease (AD), French maritime pine bark can protect vascular endothelial cells from β-amyloid-induced damage. It has been shown that French maritime bark pine has protective effects of French maritime pine bark on acrolein-induced oxidative stress in AD. French maritime bark pine significantly reduced acrolein-induced oxidative stress, protein damage, lipid peroxidation, and cell death in AD. © 2023 Elsevier Inc. All rights reserved.