Consensus Middle East and North Africa Registry on Inborn Errors of Immunity

Consensus Middle East and North Africa Registry on Inborn Errors of Immunity Publisher Pubmed

Aghamohammadi A⁶⁸ ; Rezaei N⁶⁸ ; Yazdani R⁶⁸ ; Delavari S⁶⁸ ; Kutukculer N¹ ; Topyildiz E¹ ; Ozen A^{2, 3} ; Baris S^{2, 3} ; Karakocaydiner E^{2, 3} ; Kilic SS⁴ ; Kose H⁴ ; Gulez N⁵ ; Genel F⁵ ; Reisli I⁶ Show All Authors

Aghamohammadi A⁶⁸
Rezaei N⁶⁸
Yazdani R⁶⁸
Delavari S⁶⁸
Kutukculer N¹
Topyildiz E¹
Ozen A^{2, 3}
Baris S^{2, 3}
Karakocaydiner E^{2, 3}
Kilic SS⁴
Kose H⁴
Gulez N⁵
Genel F⁵
Reisli I⁶
Djenouhat K⁷
Tahiat A⁷
Boukari R⁸
Ladj S⁸
Belbouab R⁸
Ferhani Y⁸
Belaid B⁹
Djidjik R⁹
Kechout N¹⁰
Attal N¹⁰
Saidani K¹⁰
Barbouche R¹¹
Bousfiha A¹²
Sobh A¹³
Rizk R¹³
Elnagdy MH¹⁴
Alahmed M^{15, 16}
Altamemi S¹⁷
Nasrullayeva G¹⁸
Adeli M¹⁹
Alnesf M²⁰
Hassen A¹⁹
Mehawej C²¹
Irani C²²
Megarbane A²¹
Quinn J²³
Chavoshzadeh Z³⁰
Mahdaviani SA³⁰
Nabavi M³⁰
Tavakol M³¹
Behniafard N³²
Momen T³¹
Azizi G³¹
Bemanian MH³⁰
Arshi S³⁰
Molatefi R³³
Sherkat R³¹
Shirkani A³⁴
Amin R³⁵
Aleyasin S³⁵
Faridhosseini R³⁶
Jabbariazad F³⁶
Ahanchian H³⁶
Khoshkhui M³⁶
Shafiei A³⁰
Kalantari A³⁰
Mohammadzadeh I³⁷
Ghaffari J³⁸
Cheraghi T³⁹
Mansouri M³⁰
Mesdaghi M³⁰
Babaie D³⁰
Eslamian MH⁴⁰
Dabbaghzadeh A³⁸
Tavassoli M³¹
Ghasemi R³¹
Kalmarzi RN⁴¹
Mortazavi SH⁴²
Kashef S³⁵
Tafaroji J⁴³
Khalili A³²
Zandieh F³⁰
Sadeghishabestari M⁴⁴
Darougar S³⁰
Behmanesh F³⁵
Akbari H³⁵
Zandkarimi M³⁶
Abolnezhadian F⁴⁵
Fayezi A⁴⁵
Torabizadeh M⁴⁵
Moghtaderi M³⁶
Soheili H⁴⁶
Ahmadiafshar A⁴⁷
Shakerian B³¹
Sajedi V⁴⁸
Taghvaei B⁴⁹
Safari M⁴⁰
Heidarzadeh M⁵⁰
Ghalebaghi B³⁹
Fathi SM⁵¹
Darabi B⁵²
Darabi K³⁰
Bazregari S³⁴
Bazargan N⁵³
Fallahpour M³⁰
Khayatzadeh A³⁰
Bashardoust B³⁰
Sadri H³¹
Zamani M⁵⁴
Mohsenzadeh A⁵⁵
Ebrahimi S⁵³
Ghaemi R⁵⁶
Mehrjerdi FZ³²
Sharafian S³⁰
Nabavizadeh SH³⁵
Baniadam L³⁰
Salari F³⁰
Rekabi M³⁰
Vosughimotlagh A⁵⁷
Tafakoridelbari M³⁰
Pourvali A³⁰
Rezaei A³⁰
Hamidieh AA³⁰
Shariat M³⁰
Gharagozlou M³⁰
Movahedi M³⁰
Parvaneh N³⁰
Karaca NE^{58, 59}
Aksu G^{58, 59}
Bilgic Eltan S^{60, 61, 62, 63, 64, 65}
Kasap N^{60, 61, 62, 63, 64, 65}
Kolukisa B^{60, 61, 62, 63, 64, 65}
Sefer AP^{60, 61, 62, 63, 64, 65}
Yalcin E^{60, 61, 62, 63, 64, 65}
Babayeva R^{60, 61, 62, 63, 64, 65}
Mahammed LL⁶⁶
Alkhabaz A⁶⁷
Marodi L^{24, 25, 26, 27}
Modell V^{23, 28}
Modell F^{23, 29}
Abolhassani H⁶⁸

Source: Journal of Clinical Immunology Published:2021

Abstract

Background: Inborn errors of immunity (IEIs) are a heterogeneous group of genetic defects of immunity, which cause high rates of morbidity and mortality mainly among children due to infectious and non-infectious complications. The IEI burden has been critically underestimated in countries from middle- and low-income regions and the majority of patients with IEI in these regions lack a molecular diagnosis. Methods: We analyzed the clinical, immunologic, and genetic data of IEI patients from 22 countries in the Middle East and North Africa (MENA) region. The data was collected from national registries and diverse databases such as the Asian Pacific Society for Immunodeficiencies (APSID) registry, African Society for Immunodeficiencies (ASID) registry, Jeffrey Modell Foundation (JMF) registry, J Project centers, and International Consortium on Immune Deficiency (ICID) centers. Results: We identified 17,120 patients with IEI, among which females represented 39.4%. Parental consanguinity was present in 60.5% of cases and 27.3% of the patients were from families with a confirmed previous family history of IEI. The median age of patients at the onset of disease was 36 months and the median delay in diagnosis was 41 months. The rate of registered IEI patients ranges between 0.02 and 7.58 per 100,000 population, and the lowest rates were in countries with the highest rates of disability-adjusted life years (DALY) and death rates for children. Predominantly antibody deficiencies were the most frequent IEI entities diagnosed in 41.2% of the cohort. Among 5871 patients genetically evaluated, the diagnostic yield was 83% with the majority (65.2%) having autosomal recessive defects. The mortality rate was the highest in patients with non-syndromic combined immunodeficiency (51.7%, median age: 3.5 years) and particularly in patients with mutations in specific genes associated with this phenotype (RFXANK, RAG1, and IL2RG). Conclusions: This comprehensive registry highlights the importance of a detailed investigation of IEI patients in the MENA region. The high yield of genetic diagnosis of IEI in this region has important implications for prevention, prognosis, treatment, and resource allocation. © 2021, The Author(s).

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Style	Citing Format
MLA	Aghamohammadi A, et al.. "Consensus Middle East and North Africa Registry on Inborn Errors of Immunity." Journal of Clinical Immunology, vol. 41, no. 6, 2021, pp. 1339-1351.
APA	Aghamohammadi A, Rezaei N, Yazdani R, Delavari S, Kutukculer N, Topyildiz E, Ozen A, Baris S, Karakocaydiner E, Kilic SS, Kose H, Gulez N, Genel F, Reisli I, Djenouhat K, Tahiat A, Boukari R, Ladj S, Belbouab R, ... Abolhassani H (2021). Consensus Middle East and North Africa Registry on Inborn Errors of Immunity. Journal of Clinical Immunology, 41(6), 1339-1351.
Chicago	Aghamohammadi A, Rezaei N, Yazdani R, Delavari S, Kutukculer N, Topyildiz E, Ozen A, et al.. "Consensus Middle East and North Africa Registry on Inborn Errors of Immunity." Journal of Clinical Immunology 41, no. 6 (2021): 1339-1351.
Harvard	Aghamohammadi A et al. (2021) 'Consensus Middle East and North Africa Registry on Inborn Errors of Immunity', Journal of Clinical Immunology, 41(6), pp. 1339-1351.
Vancouver	Aghamohammadi A, Rezaei N, Yazdani R, Delavari S, Kutukculer N, Topyildiz E, et al.. Consensus Middle East and North Africa Registry on Inborn Errors of Immunity. Journal of Clinical Immunology. 2021;41(6):1339-1351.
BibTex	@article{ author = {Aghamohammadi A and Rezaei N and Yazdani R and Delavari S and Kutukculer N and Topyildiz E and Ozen A and Baris S and Karakocaydiner E and Kilic SS and Kose H and Gulez N and Genel F and Reisli I and Djenouhat K and Tahiat A and Boukari R and Ladj S and Belbouab R and Ferhani Y and Belaid B and Djidjik R and Kechout N and Attal N and Saidani K and Barbouche R and Bousfiha A and Sobh A and Rizk R and Elnagdy MH and Alahmed M and Altamemi S and Nasrullayeva G and Adeli M and Alnesf M and Hassen A and Mehawej C and Irani C and Megarbane A and Quinn J and Chavoshzadeh Z and Mahdaviani SA and Nabavi M and Tavakol M and Behniafard N and Momen T and Azizi G and Bemanian MH and Arshi S and Molatefi R and Sherkat R and Shirkani A and Amin R and Aleyasin S and Faridhosseini R and Jabbariazad F and Ahanchian H and Khoshkhui M and Shafiei A and Kalantari A and Mohammadzadeh I and Ghaffari J and Cheraghi T and Mansouri M and Mesdaghi M and Babaie D and Eslamian MH and Dabbaghzadeh A and Tavassoli M and Ghasemi R and Kalmarzi RN and Mortazavi SH and Kashef S and Tafaroji J and Khalili A and Zandieh F and Sadeghishabestari M and Darougar S and Behmanesh F and Akbari H and Zandkarimi M and Abolnezhadian F and Fayezi A and Torabizadeh M and Moghtaderi M and Soheili H and Ahmadiafshar A and Shakerian B and Sajedi V and Taghvaei B and Safari M and Heidarzadeh M and Ghalebaghi B and Fathi SM and Darabi B and Darabi K and Bazregari S and Bazargan N and Fallahpour M and Khayatzadeh A and Bashardoust B and Sadri H and Zamani M and Mohsenzadeh A and Ebrahimi S and Ghaemi R and Mehrjerdi FZ and Sharafian S and Nabavizadeh SH and Baniadam L and Salari F and Rekabi M and Vosughimotlagh A and Tafakoridelbari M and Pourvali A and Rezaei A and Hamidieh AA and Shariat M and Gharagozlou M and Movahedi M and Parvaneh N and Karaca NE and Aksu G and Bilgic Eltan S and Kasap N and Kolukisa B and Sefer AP and Yalcin E and Babayeva R and Mahammed LL and Alkhabaz A and Marodi L and Modell V and Modell F and Abolhassani H}, title = {Consensus Middle East and North Africa Registry on Inborn Errors of Immunity}, journal = {Journal of Clinical Immunology}, volume = {41}, number = {6}, pages = {1339-1351}, year = {2021} }
RIS	TY - JOUR AU - Aghamohammadi A AU - Rezaei N AU - Yazdani R AU - Delavari S AU - Kutukculer N AU - Topyildiz E AU - Ozen A AU - Baris S AU - Karakocaydiner E AU - Kilic SS AU - Kose H AU - Gulez N AU - Genel F AU - Reisli I AU - Djenouhat K AU - Tahiat A AU - Boukari R AU - Ladj S AU - Belbouab R AU - Ferhani Y AU - Belaid B AU - Djidjik R AU - Kechout N AU - Attal N AU - Saidani K AU - Barbouche R AU - Bousfiha A AU - Sobh A AU - Rizk R AU - Elnagdy MH AU - Alahmed M AU - Altamemi S AU - Nasrullayeva G AU - Adeli M AU - Alnesf M AU - Hassen A AU - Mehawej C AU - Irani C AU - Megarbane A AU - Quinn J AU - Chavoshzadeh Z AU - Mahdaviani SA AU - Nabavi M AU - Tavakol M AU - Behniafard N AU - Momen T AU - Azizi G AU - Bemanian MH AU - Arshi S AU - Molatefi R AU - Sherkat R AU - Shirkani A AU - Amin R AU - Aleyasin S AU - Faridhosseini R AU - Jabbariazad F AU - Ahanchian H AU - Khoshkhui M AU - Shafiei A AU - Kalantari A AU - Mohammadzadeh I AU - Ghaffari J AU - Cheraghi T AU - Mansouri M AU - Mesdaghi M AU - Babaie D AU - Eslamian MH AU - Dabbaghzadeh A AU - Tavassoli M AU - Ghasemi R AU - Kalmarzi RN AU - Mortazavi SH AU - Kashef S AU - Tafaroji J AU - Khalili A AU - Zandieh F AU - Sadeghishabestari M AU - Darougar S AU - Behmanesh F AU - Akbari H AU - Zandkarimi M AU - Abolnezhadian F AU - Fayezi A AU - Torabizadeh M AU - Moghtaderi M AU - Soheili H AU - Ahmadiafshar A AU - Shakerian B AU - Sajedi V AU - Taghvaei B AU - Safari M AU - Heidarzadeh M AU - Ghalebaghi B AU - Fathi SM AU - Darabi B AU - Darabi K AU - Bazregari S AU - Bazargan N AU - Fallahpour M AU - Khayatzadeh A AU - Bashardoust B AU - Sadri H AU - Zamani M AU - Mohsenzadeh A AU - Ebrahimi S AU - Ghaemi R AU - Mehrjerdi FZ AU - Sharafian S AU - Nabavizadeh SH AU - Baniadam L AU - Salari F AU - Rekabi M AU - Vosughimotlagh A AU - Tafakoridelbari M AU - Pourvali A AU - Rezaei A AU - Hamidieh AA AU - Shariat M AU - Gharagozlou M AU - Movahedi M AU - Parvaneh N AU - Karaca NE AU - Aksu G AU - Bilgic Eltan S AU - Kasap N AU - Kolukisa B AU - Sefer AP AU - Yalcin E AU - Babayeva R AU - Mahammed LL AU - Alkhabaz A AU - Marodi L AU - Modell V AU - Modell F AU - Abolhassani H TI - Consensus Middle East and North Africa Registry on Inborn Errors of Immunity JO - Journal of Clinical Immunology VL - 41 IS - 6 SP - 1339 EP - 1351 PY - 2021 ER -

Style

Citing Format

MLA

Aghamohammadi A, et al.. "Consensus Middle East and North Africa Registry on Inborn Errors of Immunity." Journal of Clinical Immunology, vol. 41, no. 6, 2021, pp. 1339-1351.

APA

Aghamohammadi A, Rezaei N, Yazdani R, Delavari S, Kutukculer N, Topyildiz E, Ozen A, Baris S, Karakocaydiner E, Kilic SS, Kose H, Gulez N, Genel F, Reisli I, Djenouhat K, Tahiat A, Boukari R, Ladj S, Belbouab R, ... Abolhassani H (2021). Consensus Middle East and North Africa Registry on Inborn Errors of Immunity. Journal of Clinical Immunology, 41(6), 1339-1351.

Chicago

Aghamohammadi A, Rezaei N, Yazdani R, Delavari S, Kutukculer N, Topyildiz E, Ozen A, et al.. "Consensus Middle East and North Africa Registry on Inborn Errors of Immunity." Journal of Clinical Immunology 41, no. 6 (2021): 1339-1351.

Harvard

Aghamohammadi A et al. (2021) 'Consensus Middle East and North Africa Registry on Inborn Errors of Immunity', Journal of Clinical Immunology, 41(6), pp. 1339-1351.

Vancouver

Aghamohammadi A, Rezaei N, Yazdani R, Delavari S, Kutukculer N, Topyildiz E, et al.. Consensus Middle East and North Africa Registry on Inborn Errors of Immunity. Journal of Clinical Immunology. 2021;41(6):1339-1351.

BibTex

@article{ author = {Aghamohammadi A and Rezaei N and Yazdani R and Delavari S and Kutukculer N and Topyildiz E and Ozen A and Baris S and Karakocaydiner E and Kilic SS and Kose H and Gulez N and Genel F and Reisli I and Djenouhat K and Tahiat A and Boukari R and Ladj S and Belbouab R and Ferhani Y and Belaid B and Djidjik R and Kechout N and Attal N and Saidani K and Barbouche R and Bousfiha A and Sobh A and Rizk R and Elnagdy MH and Alahmed M and Altamemi S and Nasrullayeva G and Adeli M and Alnesf M and Hassen A and Mehawej C and Irani C and Megarbane A and Quinn J and Chavoshzadeh Z and Mahdaviani SA and Nabavi M and Tavakol M and Behniafard N and Momen T and Azizi G and Bemanian MH and Arshi S and Molatefi R and Sherkat R and Shirkani A and Amin R and Aleyasin S and Faridhosseini R and Jabbariazad F and Ahanchian H and Khoshkhui M and Shafiei A and Kalantari A and Mohammadzadeh I and Ghaffari J and Cheraghi T and Mansouri M and Mesdaghi M and Babaie D and Eslamian MH and Dabbaghzadeh A and Tavassoli M and Ghasemi R and Kalmarzi RN and Mortazavi SH and Kashef S and Tafaroji J and Khalili A and Zandieh F and Sadeghishabestari M and Darougar S and Behmanesh F and Akbari H and Zandkarimi M and Abolnezhadian F and Fayezi A and Torabizadeh M and Moghtaderi M and Soheili H and Ahmadiafshar A and Shakerian B and Sajedi V and Taghvaei B and Safari M and Heidarzadeh M and Ghalebaghi B and Fathi SM and Darabi B and Darabi K and Bazregari S and Bazargan N and Fallahpour M and Khayatzadeh A and Bashardoust B and Sadri H and Zamani M and Mohsenzadeh A and Ebrahimi S and Ghaemi R and Mehrjerdi FZ and Sharafian S and Nabavizadeh SH and Baniadam L and Salari F and Rekabi M and Vosughimotlagh A and Tafakoridelbari M and Pourvali A and Rezaei A and Hamidieh AA and Shariat M and Gharagozlou M and Movahedi M and Parvaneh N and Karaca NE and Aksu G and Bilgic Eltan S and Kasap N and Kolukisa B and Sefer AP and Yalcin E and Babayeva R and Mahammed LL and Alkhabaz A and Marodi L and Modell V and Modell F and Abolhassani H}, title = {Consensus Middle East and North Africa Registry on Inborn Errors of Immunity}, journal = {Journal of Clinical Immunology}, volume = {41}, number = {6}, pages = {1339-1351}, year = {2021} }

RIS

TY - JOUR
AU - Aghamohammadi A
AU - Rezaei N
AU - Yazdani R
AU - Delavari S
AU - Kutukculer N
AU - Topyildiz E
AU - Ozen A
AU - Baris S
AU - Karakocaydiner E
AU - Kilic SS
AU - Kose H
AU - Gulez N
AU - Genel F
AU - Reisli I
AU - Djenouhat K
AU - Tahiat A
AU - Boukari R
AU - Ladj S
AU - Belbouab R
AU - Ferhani Y
AU - Belaid B
AU - Djidjik R
AU - Kechout N
AU - Attal N
AU - Saidani K
AU - Barbouche R
AU - Bousfiha A
AU - Sobh A
AU - Rizk R
AU - Elnagdy MH
AU - Alahmed M
AU - Altamemi S
AU - Nasrullayeva G
AU - Adeli M
AU - Alnesf M
AU - Hassen A
AU - Mehawej C
AU - Irani C
AU - Megarbane A
AU - Quinn J
AU - Chavoshzadeh Z
AU - Mahdaviani SA
AU - Nabavi M
AU - Tavakol M
AU - Behniafard N
AU - Momen T
AU - Azizi G
AU - Bemanian MH
AU - Arshi S
AU - Molatefi R
AU - Sherkat R
AU - Shirkani A
AU - Amin R
AU - Aleyasin S
AU - Faridhosseini R
AU - Jabbariazad F
AU - Ahanchian H
AU - Khoshkhui M
AU - Shafiei A
AU - Kalantari A
AU - Mohammadzadeh I
AU - Ghaffari J
AU - Cheraghi T
AU - Mansouri M
AU - Mesdaghi M
AU - Babaie D
AU - Eslamian MH
AU - Dabbaghzadeh A
AU - Tavassoli M
AU - Ghasemi R
AU - Kalmarzi RN
AU - Mortazavi SH
AU - Kashef S
AU - Tafaroji J
AU - Khalili A
AU - Zandieh F
AU - Sadeghishabestari M
AU - Darougar S
AU - Behmanesh F
AU - Akbari H
AU - Zandkarimi M
AU - Abolnezhadian F
AU - Fayezi A
AU - Torabizadeh M
AU - Moghtaderi M
AU - Soheili H
AU - Ahmadiafshar A
AU - Shakerian B
AU - Sajedi V
AU - Taghvaei B
AU - Safari M
AU - Heidarzadeh M
AU - Ghalebaghi B
AU - Fathi SM
AU - Darabi B
AU - Darabi K
AU - Bazregari S
AU - Bazargan N
AU - Fallahpour M
AU - Khayatzadeh A
AU - Bashardoust B
AU - Sadri H
AU - Zamani M
AU - Mohsenzadeh A
AU - Ebrahimi S
AU - Ghaemi R
AU - Mehrjerdi FZ
AU - Sharafian S
AU - Nabavizadeh SH
AU - Baniadam L
AU - Salari F
AU - Rekabi M
AU - Vosughimotlagh A
AU - Tafakoridelbari M
AU - Pourvali A
AU - Rezaei A
AU - Hamidieh AA
AU - Shariat M
AU - Gharagozlou M
AU - Movahedi M
AU - Parvaneh N
AU - Karaca NE
AU - Aksu G
AU - Bilgic Eltan S
AU - Kasap N
AU - Kolukisa B
AU - Sefer AP
AU - Yalcin E
AU - Babayeva R
AU - Mahammed LL
AU - Alkhabaz A
AU - Marodi L
AU - Modell V
AU - Modell F
AU - Abolhassani H
TI - Consensus Middle East and North Africa Registry on Inborn Errors of Immunity
JO - Journal of Clinical Immunology
VL - 41
IS - 6
SP - 1339
EP - 1351
PY - 2021
ER -

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