Mitochondria As Playmakers of Car T-Cell Fate and Longevity

Mitochondria As Playmakers of Car T-Cell Fate and Longevity Publisher Pubmed

Rostamian H¹ ; Khakpoorkoosheh M¹ ; Fallahmehrjardi K¹ ; Mirzaei HR¹ ; Brown CE^{2, 3}

Show Affiliations

1. Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Hematology and Hematopoietic Cell Transplantation, City of Hope Medical Center, Duarte, CA, United States
3. Depart-ment of Immuno-Oncology, City of Hope Beckman Research Institute, Duarte, CA, United States

Source: Cancer Immunology Research Published:2021

Abstract

The development of chimeric antigen receptor (CAR) T-cell therapy has led to a paradigm shift in cancer treatment. However, patients often do not benefit from CAR T-cell therapy due to poor persistence of the adoptively transferred cells. Development of strategies based on the generation and maintenance of long-lasting memory T cells may expand the therapeutic effects of CAR T cells. Mitochondrial metabolic pathways play crucial roles in regulating the fate, function, and longevity of T cells. Here, we discuss how reprogramming of mitochondrial metabolic pathways influences function, persistence, and determination of CAR T-cell fate toward a memory phenotype. Moreover, we explore how mitochondrial activity determines persistence and the clinical outcome of CAR T-cell therapy. In addition, we review some strategies for manipulating CAR T-cell mitochondria to improve the survival of CAR T cells. © 2021 American Association for Cancer Research

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Style	Citing Format
MLA	Rostamian H, et al.. "Mitochondria As Playmakers of Car T-Cell Fate and Longevity." Cancer Immunology Research, vol. 9, no. 8, 2021, pp. 856-861.
APA	Rostamian H, Khakpoorkoosheh M, Fallahmehrjardi K, Mirzaei HR, Brown CE (2021). Mitochondria As Playmakers of Car T-Cell Fate and Longevity. Cancer Immunology Research, 9(8), 856-861.
Chicago	Rostamian H, Khakpoorkoosheh M, Fallahmehrjardi K, Mirzaei HR, Brown CE. "Mitochondria As Playmakers of Car T-Cell Fate and Longevity." Cancer Immunology Research 9, no. 8 (2021): 856-861.
Harvard	Rostamian H et al. (2021) 'Mitochondria As Playmakers of Car T-Cell Fate and Longevity', Cancer Immunology Research, 9(8), pp. 856-861.
Vancouver	Rostamian H, Khakpoorkoosheh M, Fallahmehrjardi K, Mirzaei HR, Brown CE. Mitochondria As Playmakers of Car T-Cell Fate and Longevity. Cancer Immunology Research. 2021;9(8):856-861.
BibTex	@article{ author = {Rostamian H and Khakpoorkoosheh M and Fallahmehrjardi K and Mirzaei HR and Brown CE}, title = {Mitochondria As Playmakers of Car T-Cell Fate and Longevity}, journal = {Cancer Immunology Research}, volume = {9}, number = {8}, pages = {856-861}, year = {2021} }
RIS	TY - JOUR AU - Rostamian H AU - Khakpoorkoosheh M AU - Fallahmehrjardi K AU - Mirzaei HR AU - Brown CE TI - Mitochondria As Playmakers of Car T-Cell Fate and Longevity JO - Cancer Immunology Research VL - 9 IS - 8 SP - 856 EP - 861 PY - 2021 ER -

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