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A Review of the Potential Role of Coq10 in the Treatment of Hepatocellular Carcinoma Publisher Pubmed



Liaghat M1 ; Yaghoubzadmaleki M2 ; Nabiafjadi M3 ; Fathi Z4 ; Zalpoor H5 ; Heidari N6 ; Bahreini E6
Authors
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Authors Affiliations
  1. 1. Department of Medical Laboratory Sciences, Faculty of Medical Sciences, Kazerun Branch, Islamic Azad University, Kazerun, Iran
  2. 2. Division of Biochemistry, Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
  3. 3. Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
  4. 4. Medical School, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Shiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  6. 6. Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, P.O. Box: 1449614525, Tehran, Iran

Source: Biochemical Genetics Published:2024


Abstract

The coenzyme ubiquinone-10 (CoQ10) is not only an important part of the electron transport chain of the mitochondrial inner membrane but also has complex biological functions beyond mitochondrial respiration. It is a natural nutrient that is not only produced by the body but is also found in foods, such as meat, eggs, fish, and vegetable oils. Because some types of cancer reduce CoQ10 blood levels, the use of CoQ10 supplements is recommended for the treatment of cancer patients. The anti-cancer effects of CoQ10 supplementation have been reported in several cancers, including colon and breast cancer. CoQ10 scavenges free radicals to reduce oxidative stress and minimize tissue damage. CoQ10 protects the body from damage caused by chemotherapy drugs by reducing the production of inflammatory cytokines and other inflammatory factors. Recent studies suggest that CoQ10 may be a supplement to pharmacotherapy for hepatocellular carcinoma. This article examines the effects of CoQ10 in hepatocellular carcinoma. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023.
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