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Prospects and Challenges of Anticancer Agents’ Delivery Via Chitosan-Based Drug Carriers to Combat Breast Cancer: A Review Publisher Pubmed



Wang G1 ; Li R1 ; Parseh B2 ; Du G3
Authors
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Authors Affiliations
  1. 1. Guangxi Medical College, Nanning, 530023, Guangxi, China
  2. 2. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China

Source: Carbohydrate Polymers Published:2021


Abstract

Breast cancer (BC) is considered as one the most prevalent cancers worldwide. Due to its high resistance to chemotherapy and high probability of metastasis, BC is one of the leading causes of cancer-related deaths. The controlled release of chemotherapy drugs to the precise site of the tumor tissue will increase the therapeutic efficacy and decrease side effects of systemic administration. Among various drug delivery systems, natural polymers-based drug carriers have gained significant attention for cancer therapy. Chitosan, a natural polymer obtained by de-acetylation of chitin, holds huge potential for drug delivery applications because chitosan is non-toxic, non-immunogenic, biocompatible, chemically modifiable, and can be processed to form various formulations. In the current review, we will discuss the prospects and challenges of chitosan-based drug delivery systems in treating BC. © 2021 Elsevier Ltd
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