Effects of L-Carnitine Supplementation on Biomarkers of Oxidative Stress, Antioxidant Capacity and Lipid Profile, in Patients With Pemphigus Vulgaris: A Randomized, Double-Blind, Placebo-Controlled Trial Publisher



Mohammadi H¹ ; Djalali M¹ ; Daneshpazhooh M² ; Honarvar NM¹ ; Chamsdavatchi C² ; Sepandar F¹ ; Fakhri Z¹ ; Yaghubi E¹ ; Zarei M¹ ; Javanbakht MH¹ Show Affiliations
Source: European Journal of Clinical Nutrition Published:2018

Abstract

Background/Objectives:Pemphigus vulgaris (PV), as an autoimmune disease including mucosa and the skin, is associated with several complications and comorbidities. The present study planned to determine the effect of L-carnitine (LC) supplementation on biomarkers of oxidative stress (OS), antioxidant capacity and lipid profile in PV patients.Subjects/MethodsFifty two control and patients with PV, participated in the current randomized, double-blind, placebo-controlled clinical trial. The patients were allocated randomly to receive 2 g per day LC tartrate subdivided into two equal doses of 1 g before breakfast and dinner (n=26) or placebo (n=26) for 8 weeks. Anthropometric, lipid profile and OS values were determined at baseline and end of intervention period.Results:LC intake significantly reduced serum levels of triglycerides, total-, LDL-cholesterol and oxidative stress index (OSI; P<0.05). In addition, supplementation with LC resulted to a meaningful increase in levels of total antioxidant capacity (TAC) (P=0.05) and serum carnitine (P<0.001). LC intake revealed non-significant change in serum total oxidant capacity (P=0.15) and HDL-cholesterol (P=0.06) in comparison to the placebo.Conclusions:LC consumption may have favorable results on TAC, OSI and lipid profiles in patients with PV. The results were in line with the idea that LC supplementation can be associated with positive effects on metabolic status and OS of patients with PV. © 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.