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Relationship Between Diet-Related Inflammation and Hospitalization Risk and Disease Severity in Patients With Covid-19 Publisher



Z Yari ZAHRA ; S Ebrahimof SAMIRA ; S Soltanieh SAMIRA ; Mr Salavatizadeh Marieh R ; S Karimi SARA ; Sk Ardestani Susan KABUDANIAN ; Mr Salehi Mohammad REZA ; Sm Razeghijahromi Soodeh M ; T Ghazanfari TOOBA ; A Hekmatdoost AZITA
Authors

Source: Journal of Nutrition and Food Security Published:2024


Abstract

Background: Increased serum concentrations of inflammatory biomarkers in patients indicate a strong association between COVID-19 and inflammation. However, the association between diet-related inflammation and COVID-19 has been less investigated. The aim of this study is to investigate whether the inflammatory scores of the diet are associated with the severity of COVID-19 disease and the probability of hospitalization of patients. Methods: The authors conducted a cross-sectional study involving 141 patients with COVID-19. The empirical dietary inflammatory pattern (EDIP) and dietary inflammation scores (DIS) were calculated based on a 147-item semi-quantitative food frequency questionnaire. The association between serum levels of inflammatory biomarkers and diet-related inflammation was also investigated. Results: 74 inpatients and 87 outpatients participated in this study. Higher DIS scores were significantly associated with an increased risk of COVID-related hospitalization (Tertile3 vs. tertile1: OR = 3·62; 95 % CI 1·43 to 9·14, P=0·008 after fully adjustment). This association with EDIP was also observed, but it was not significant. Conclusion: The data from this provide evidence that a pro-inflammatory diet was associated with higher risk of hospitalization due to high severity of COVID-19. © 2024 Elsevier B.V., All rights reserved.
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