Hlf Is a Promising Prognostic, Immunological, and Therapeutic Biomarker in Human Tumors Publisher



Ahmadi M^{1, 2} ; Mohajeri Khorasani A¹ ; Morshedzadeh F^{3, 4} ; Saffarzadeh N⁵ ; Ghaderian SMH² ; Ghafourifard S² ; Mousavi P⁶ Show Affiliations
Source: Biochemistry and Biophysics Reports Published:2024

Abstract

Despite past research linking HLF mutations to cancer development, no pan-cancer analyses of HLF have been published. As a result, we utilized multiple databases to illustrate the potential roles of HLF in diverse types of cancers. Several databases were used to assess HLF expression in the TCGA cancer samples. Additional assessments were undertaken to investigate the relationship between HLF and overall survival, immune cell infiltration, genetic alterations, promoter methylation, and protein-protein interaction. HLF's putative roles and the relationship between HLF expression and drug reactivity were investigated. HLF expression was shown to be lower in tumor tissues from a variety of malignancies when compared to normal tissues. There was a substantial link found between HLF expression and patient survival, genetic mutations, and immunological infiltration. HLF influenced the pathways of apoptosis, cell cycle, EMT, and PI3K/AKT signaling. Abnormal expression of HLF lowered sensitivity to numerous anti-tumor drugs and small compounds. According to our findings, reduced HLF expression drives cancer growth, and it has the potential to be identified as a vital biomarker for use in prognosis, immunotherapy, and targeted treatment of a range of malignancies. © 2024 The Author(s)