Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Vitamin D in Migraine Headache: A Comprehensive Review on Literature Publisher Pubmed



Ghorbani Z1, 2 ; Togha M2 ; Rafiee P3 ; Ahmadi ZS4 ; Rasekh Magham R5 ; Haghighi S2 ; Razeghi Jahromi S6 ; Mahmoudi M1, 7, 8
Authors

Source: Neurological Sciences Published:2019


Abstract

Introduction: As a primary headache, migraine has been established as the first leading disability cause worldwide in the subjects who aged less than 50 years. A variety of dietary supplements have been introduced for migraine complementary treatment. As an anti-inflammatory and antioxidant agent, vitamin D is one of these agents which has been of interest in recent years. Although higher prevalence of vitamin D deficiency/insufficiency has been highlighted among migraineurs compared to controls, there is not any consensus in prescribing vitamin D in clinical practice. Therefore, in the current review, in addition to observational and case-control studies, we also included clinical trials concerning the effects of vitamin D supplementation on migraine/headache. Methods: Based on a PubMed/MEDLINE and ScienceDirect database search, this review study includes published articles up to June 2019 concerning the association between migraine/headache and vitamin D status or supplementation. Results: The percentage of subjects with vitamin D deficiency and insufficiency among migraineurs and headache patients has been reported to vary between 45 and 100%. In a number of studies, vitamin D level was negatively correlated with frequency of headaches. The present findings show that supplementation with this vitamin in a dose of 1000–4000 IU/d could reduce the frequency of attacks in migraineurs. Conclusion: It seems a high proportion of migraine patients might suffer from vitamin D deficiency/insufficiency. Further, the current evidence shows that in addition to routine drug therapy, vitamin D administration might reduce the frequency of attacks in migraineurs. However, these results have yet to be confirmed. © 2019, Fondazione Societa Italiana di Neurologia.
Other Related Docs
4. Review on Headache Related to Dietary Supplements, Current Pain and Headache Reports (2022)
6. Evaluation of Inflammatory State in Migraineurs: A Case-Control Study, Iranian Journal of Allergy# Asthma and Immunology (2020)
10. Association of Diet and Headache, Journal of Headache and Pain (2019)
15. Dietary Supplementation in Migraine: A Focus on Omega-3 Fatty Acids, Treatments# Nutraceuticals# Supplements# and Herbal Medicine in Neurological Disorders (2023)
16. Gut-Brain Axis and Migraine Headache: A Comprehensive Review, Journal of Headache and Pain (2020)