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Integration of Polysaccharide Electrospun Nanofibers With Microneedle Arrays Promotes Wound Regeneration: A Review Publisher Pubmed



Kolahi Azar H1, 2 ; Hajian Monfared M3, 14 ; Seraji AA4, 5 ; Nazarnezhad S6, 14 ; Nasiri E7 ; Zeinanloo N8 ; Sherafati M9 ; Sharifianjazi F10 ; Rostami M11, 12 ; Beheshtizadeh N13, 14
Authors
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Authors Affiliations
  1. 1. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Department of Pathology, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Department of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Canada
  5. 5. Department of Polymer Engineering and Color Technology, Amirkabir University of Technology, Tehran, Iran
  6. 6. Tissue Engineering Research Group (TERG), Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. School of Metallurgy and Materials Engineering, University of Tehran, Tehran, Iran
  8. 8. Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
  9. 9. Department of Biomedical Engineering, Islamic Azad University, Mashhad, Iran
  10. 10. Department of Natural Sciences, School of Science and Technology, The University of Georgia, Tbilisi, 0171, Georgia
  11. 11. Division of Food Safety and Hygiene, Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  12. 12. Food Science and Nutrition Group (FSAN), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  13. 13. Department of Tissue Engineering, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  14. 14. Regenerative Medicine group (REMED), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: International Journal of Biological Macromolecules Published:2024


Abstract

Utilizing electrospun nanofibers and microneedle arrays in wound regeneration has been practiced for several years. Researchers have recently asserted that using multiple methods concurrently might enhance efficiency, despite the inherent strengths and weaknesses of each individual approach. The combination of microneedle arrays with electrospun nanofibers has the potential to create a drug delivery system and wound healing method that offer improved efficiency and accuracy in targeting. The use of microneedles with nanofibers allows for precise administration of pharmaceuticals due to the microneedles' capacity to pierce the skin and the nanofibers' role as a drug reservoir, resulting in a progressive release of drugs over a certain period of time. Electrospun nanofibers have the ability to imitate the extracellular matrix and provide a framework for cellular growth and tissue rejuvenation, while microneedle arrays show potential for enhancing tissue regeneration and enhancing the efficacy of wound healing. The integration of electrospun nanofibers with microneedle arrays may be customized to effectively tackle particular obstacles in the fields of wound healing and drug delivery. However, some issues must be addressed before this paradigm may be fully integrated into clinical settings, including but not limited to ensuring the safety and sterilization of these products for transdermal use, optimizing manufacturing methods and characterization of developed products, larger-scale production, optimizing storage conditions, and evaluating the inclusion of multiple therapeutic and antimicrobial agents to increase the synergistic effects in the wound healing process. This research examines the combination of microneedle arrays with electrospun nanofibers to enhance the delivery of drugs and promote wound healing. It explores various kinds of microneedle arrays, the materials and processes used, and current developments in their integration with electrospun nanofibers. © 2023 Elsevier B.V.
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