Obesity Is Associated With Biliary Tract Cancer Mortality and Incidence: A Pooled Analysis of 21 Cohort Studies in the Asia Cohort Consortium

Obesity Is Associated With Biliary Tract Cancer Mortality and Incidence: A Pooled Analysis of 21 Cohort Studies in the Asia Cohort Consortium Publisher Pubmed

Oze I¹ ; Ito H^{2, 3} ; Koyanagi YN² ; Abe SK⁴ ; Rahman MS^{4, 5} ; Islam MR^{4, 6} ; Saito E⁷ ; Gupta PC⁸ ; Sawada N⁹ ; Tamakoshi A¹⁰ ; Shu XO¹¹ ; Sakata R¹² ; Malekzadeh R¹³ ; Tsuji I¹⁴ Show All Authors

Oze I¹
Ito H^{2, 3}
Koyanagi YN²
Abe SK⁴
Rahman MS^{4, 5}
Islam MR^{4, 6}
Saito E⁷
Gupta PC⁸
Sawada N⁹
Tamakoshi A¹⁰
Shu XO¹¹
Sakata R¹²
Malekzadeh R¹³
Tsuji I¹⁴
Kim J¹⁵
Nagata C¹⁶
You SL¹⁷
Park SK¹⁸
Yuan JM^{19, 20}
Shin MH²¹
Kweon SS²²
Pednekar MS⁸
Tsugane S^{9, 23}
Kimura T¹⁰
Gao YT^{24, 25}
Cai H¹¹
Pourshams A²⁶
Lu Y¹⁴
Kanemura S¹⁴
Wada K¹⁶
Sugawara Y¹⁴
Chen CJ²⁷
Chen Y²⁸
Shin A^{18, 29}
Wang R¹⁹
Ahn YO¹⁸
Shin MH²¹
Ahsan H³⁰
Boffetta P^{31, 32}
Chia KS³³
Qiao YL³⁴
Rothman N³⁵
Zheng W¹¹
Inoue M⁴
Kang D³⁶
Matsuo K^{1, 37}

Show Affiliations

1. Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
2. Division of Cancer Information and Control, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan
3. Division of Descriptive Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
4. Division of Prevention, National Cancer Center Institute for Cancer Control, Tokyo, Japan
5. Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
6. Hitotsubashi Institute for Advanced Study, Hitotsubashi University, Tokyo, Japan
7. Institute for Global Health Policy Research, National Center for Global Health and Medicine, Tokyo, Japan
8. Healisâ€”Sekhsaria Institute for Public Health, Navi Mumbai, India
9. Division of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, Japan
10. Department of Public Health, Hokkaido University Faculty of Medicine, Sapporo, Japan
11. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, United States
12. Radiation Effects Research Foundation, Hiroshima, Japan
13. Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
14. Tohoku University Graduate School of Medicine, Miyagi, Japan
15. Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, South Korea
16. Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
17. School of Medicine & Big Data Research Center, Fu Jen Catholic University, Taipei, Taiwan
18. Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea
19. Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, United States
20. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States
21. Department of Social and Preventive Medicine, Sungkyunkwan University School of Medicine, Gyeonggi-do, South Korea
22. Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea
23. National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan
24. Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China
25. Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
26. Digestive Diseases Research institute, Tehran University of Medical Science, Tehran, Iran
27. Genomics Research Center, Academia Sinica, Taipei, Taiwan
28. Departments of Population Health and Environmental Medicine, NYU Grossman School of Medicine, New York, NY, United States
29. Cancer Research Institute, Seoul National University, Seoul, South Korea
30. Department of Public Health Sciences, University of Chicago, Chicago, IL, United States
31. Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY, United States
32. Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
33. Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore
34. School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
35. Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD, United States
36. Seoul National University College of Medicine, Seoul, South Korea
37. Department of Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan

Source: International Journal of Cancer Published:2024

Abstract

Body fatness is considered a probable risk factor for biliary tract cancer (BTC), whereas cholelithiasis is an established factor. Nevertheless, although obesity is an established risk factor for cholelithiasis, previous studies of the association of body mass index (BMI) and BTC did not take the effect of cholelithiasis fully into account. To better understand the effect of BMI on BTC, we conducted a pooled analysis using population-based cohort studies in Asians. In total, 905 530 subjects from 21 cohort studies participating in the Asia Cohort Consortium were included. BMI was categorized into four groups: underweight (<18.5 kg/m2); normal (18.5-22.9 kg/m2); overweight (23-24.9 kg/m2); and obese (25+ kg/m2). The association between BMI and BTC incidence and mortality was assessed using hazard ratios (HR) and 95% confidence intervals (CIs) by Cox regression models with shared frailty. Mediation analysis was used to decompose the association into a direct and an indirect (mediated) effect. Compared to normal BMI, high BMI was associated with BTC mortality (HR 1.19 [CI 1.02-1.38] for males, HR 1.30 [1.14-1.49] for females). Cholelithiasis had significant interaction with BMI on BTC risk. BMI was associated with BTC risk directly and through cholelithiasis in females, whereas the association was unclear in males. When cholelithiasis was present, BMI was not associated with BTC death in either males or females. BMI was associated with BTC death among females without cholelithiasis. This study suggests BMI is associated with BTC mortality in Asians. Cholelithiasis appears to contribute to the association; and moreover, obesity appears to increase BTC risk without cholelithiasis. © 2023 UICC.

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Style	Citing Format
MLA	Oze I, et al.. "Obesity Is Associated With Biliary Tract Cancer Mortality and Incidence: A Pooled Analysis of 21 Cohort Studies in the Asia Cohort Consortium." International Journal of Cancer, vol. 154, no. 7, 2024, pp. 1174-1190.
APA	Oze I, Ito H, Koyanagi YN, Abe SK, Rahman MS, Islam MR, Saito E, Gupta PC, Sawada N, Tamakoshi A, Shu XO, Sakata R, Malekzadeh R, Tsuji I, Kim J, Nagata C, You SL, Park SK, Yuan JM, ... Matsuo K (2024). Obesity Is Associated With Biliary Tract Cancer Mortality and Incidence: A Pooled Analysis of 21 Cohort Studies in the Asia Cohort Consortium. International Journal of Cancer, 154(7), 1174-1190.
Chicago	Oze I, Ito H, Koyanagi YN, Abe SK, Rahman MS, Islam MR, Saito E, et al.. "Obesity Is Associated With Biliary Tract Cancer Mortality and Incidence: A Pooled Analysis of 21 Cohort Studies in the Asia Cohort Consortium." International Journal of Cancer 154, no. 7 (2024): 1174-1190.
Harvard	Oze I et al. (2024) 'Obesity Is Associated With Biliary Tract Cancer Mortality and Incidence: A Pooled Analysis of 21 Cohort Studies in the Asia Cohort Consortium', International Journal of Cancer, 154(7), pp. 1174-1190.
Vancouver	Oze I, Ito H, Koyanagi YN, Abe SK, Rahman MS, Islam MR, et al.. Obesity Is Associated With Biliary Tract Cancer Mortality and Incidence: A Pooled Analysis of 21 Cohort Studies in the Asia Cohort Consortium. International Journal of Cancer. 2024;154(7):1174-1190.
BibTex	@article{ author = {Oze I and Ito H and Koyanagi YN and Abe SK and Rahman MS and Islam MR and Saito E and Gupta PC and Sawada N and Tamakoshi A and Shu XO and Sakata R and Malekzadeh R and Tsuji I and Kim J and Nagata C and You SL and Park SK and Yuan JM and Shin MH and Kweon SS and Pednekar MS and Tsugane S and Kimura T and Gao YT and Cai H and Pourshams A and Lu Y and Kanemura S and Wada K and Sugawara Y and Chen CJ and Chen Y and Shin A and Wang R and Ahn YO and Shin MH and Ahsan H and Boffetta P and Chia KS and Qiao YL and Rothman N and Zheng W and Inoue M and Kang D and Matsuo K}, title = {Obesity Is Associated With Biliary Tract Cancer Mortality and Incidence: A Pooled Analysis of 21 Cohort Studies in the Asia Cohort Consortium}, journal = {International Journal of Cancer}, volume = {154}, number = {7}, pages = {1174-1190}, year = {2024} }
RIS	TY - JOUR AU - Oze I AU - Ito H AU - Koyanagi YN AU - Abe SK AU - Rahman MS AU - Islam MR AU - Saito E AU - Gupta PC AU - Sawada N AU - Tamakoshi A AU - Shu XO AU - Sakata R AU - Malekzadeh R AU - Tsuji I AU - Kim J AU - Nagata C AU - You SL AU - Park SK AU - Yuan JM AU - Shin MH AU - Kweon SS AU - Pednekar MS AU - Tsugane S AU - Kimura T AU - Gao YT AU - Cai H AU - Pourshams A AU - Lu Y AU - Kanemura S AU - Wada K AU - Sugawara Y AU - Chen CJ AU - Chen Y AU - Shin A AU - Wang R AU - Ahn YO AU - Shin MH AU - Ahsan H AU - Boffetta P AU - Chia KS AU - Qiao YL AU - Rothman N AU - Zheng W AU - Inoue M AU - Kang D AU - Matsuo K TI - Obesity Is Associated With Biliary Tract Cancer Mortality and Incidence: A Pooled Analysis of 21 Cohort Studies in the Asia Cohort Consortium JO - International Journal of Cancer VL - 154 IS - 7 SP - 1174 EP - 1190 PY - 2024 ER -

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