Dietary Intake of Minerals and Risk of Esophageal Squamous Cell Carcinoma: Results From the Golestan Cohort Study

Dietary Intake of Minerals and Risk of Esophageal Squamous Cell Carcinoma: Results From the Golestan Cohort Study Publisher Pubmed

Hashemian M¹ ; Poustchi H³ ; Abnet CC⁵ ; Boffetta P⁶ ; Dawsey SM⁵ ; Brennan PJ⁷ ; Pharoah P⁸ ; Etemadi A^{4, 5} ; Kamangar F^{4, 5} ; Sharafkhah M³ ; Hekmatdoost A² ; Malekzadeh R⁴

Show Affiliations

1. International Branch, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Departments of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
4. Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
5. Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States
6. Icahn School of Medicine at Mount Sinai, New York, NY, United States
7. International Agency for Research on Cancer, Lyon, France
8. Cancer Research UK, Department of Oncology, Cambridge University, Cambridge, United Kingdom

Source: American Journal of Clinical Nutrition Published:2015

Abstract

Background: Dietary factors have been hypothesized to affect the risk of esophageal cancer via different mechanisms, but the intake of minerals is understudied and the evidence is conflicting. Objective: The objective was to evaluate the associations of dietary intake of minerals with risk of esophageal squamous cell carcinoma (ESCC). Design: We used data from the Golestan Cohort Study, which was launched in a high-risk region for esophageal cancer in Iran. Participants were enrolled in 2004-2008 and were followed to 2014. Intakes of minerals were assessed with a validated food-frequency questionnaire. A Cox proportional hazards model was used to estimate HRs and 95% CIs of ESCC for dietary intakes of selected minerals. Results: We identified 201 ESCC cases among 47,405 subjects. Calcium intake was significantly inversely associated with the risk of ESCC (HR per 100-mg/d increase: 0.88; 95% CI: 0.81, 0.96; P = 0.005; quartile 4 vs. quartile 1 HR: 0.49; 95% CI: 0.29, 0.82; Ptrend = 0.013). Zinc intake was also inversely associated with ESCC, but the quartile association did not reach significance (HR per 1-mg/d increase: 0.87; 95% CI: 0.77, 0.98; P = 0.027; quartile 4 vs. quartile 1 HR: 0.56; 95% CI: 0.28, 1.12; P-trend = 0.097). The relations between dietary intakes of selenium, magnesium, and copper and risk of ESCC were nonlinear (P-nonlinear trend = 0.001, 0.016, and 0.029, respectively). There was no relation between dietary intake of manganese and the risk of ESCC. Conclusion: The results suggest that higher intakes of calcium and zinc are associated with a lower risk of ESCC in a high-risk region of Iran. © 2015 American Society for Nutrition.

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Hossein Poustchi (75)

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Style	Citing Format
MLA	Hashemian M, et al.. "Dietary Intake of Minerals and Risk of Esophageal Squamous Cell Carcinoma: Results From the Golestan Cohort Study." American Journal of Clinical Nutrition, vol. 102, no. 1, 2015, pp. 102-108.
APA	Hashemian M, Poustchi H, Abnet CC, Boffetta P, Dawsey SM, Brennan PJ, Pharoah P, Etemadi A, Kamangar F, Sharafkhah M, Hekmatdoost A, Malekzadeh R (2015). Dietary Intake of Minerals and Risk of Esophageal Squamous Cell Carcinoma: Results From the Golestan Cohort Study. American Journal of Clinical Nutrition, 102(1), 102-108.
Chicago	Hashemian M, Poustchi H, Abnet CC, Boffetta P, Dawsey SM, Brennan PJ, Pharoah P, et al.. "Dietary Intake of Minerals and Risk of Esophageal Squamous Cell Carcinoma: Results From the Golestan Cohort Study." American Journal of Clinical Nutrition 102, no. 1 (2015): 102-108.
Harvard	Hashemian M et al. (2015) 'Dietary Intake of Minerals and Risk of Esophageal Squamous Cell Carcinoma: Results From the Golestan Cohort Study', American Journal of Clinical Nutrition, 102(1), pp. 102-108.
Vancouver	Hashemian M, Poustchi H, Abnet CC, Boffetta P, Dawsey SM, Brennan PJ, et al.. Dietary Intake of Minerals and Risk of Esophageal Squamous Cell Carcinoma: Results From the Golestan Cohort Study. American Journal of Clinical Nutrition. 2015;102(1):102-108.
BibTex	@article{ author = {Hashemian M and Poustchi H and Abnet CC and Boffetta P and Dawsey SM and Brennan PJ and Pharoah P and Etemadi A and Kamangar F and Sharafkhah M and Hekmatdoost A and Malekzadeh R}, title = {Dietary Intake of Minerals and Risk of Esophageal Squamous Cell Carcinoma: Results From the Golestan Cohort Study}, journal = {American Journal of Clinical Nutrition}, volume = {102}, number = {1}, pages = {102-108}, year = {2015} }
RIS	TY - JOUR AU - Hashemian M AU - Poustchi H AU - Abnet CC AU - Boffetta P AU - Dawsey SM AU - Brennan PJ AU - Pharoah P AU - Etemadi A AU - Kamangar F AU - Sharafkhah M AU - Hekmatdoost A AU - Malekzadeh R TI - Dietary Intake of Minerals and Risk of Esophageal Squamous Cell Carcinoma: Results From the Golestan Cohort Study JO - American Journal of Clinical Nutrition VL - 102 IS - 1 SP - 102 EP - 108 PY - 2015 ER -

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