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The Role of Nanotechnology in Overcoming Barriers to Phage Therapy: An Overview Publisher



Mohammadi M1 ; Mirabadi M2 ; Beig M3 ; Nasereslami S4 ; Yazdanmehr M5 ; Monfared FN6
Authors
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Authors Affiliations
  1. 1. Microbiology and Immunology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  2. 2. Department of Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Microbiology, Pasteur Institute of Iran, Tehran, Iran
  4. 4. Department of Virology, Faculty of Medicine, Tarbiat Modares University, Tehran, Iran
  5. 5. Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  6. 6. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Future Virology Published:2023


Abstract

Phage treatment has again risen in popularity due to the rise of antibiotic resistance and the need for more reliable alternatives. Human approval of phage therapy has been delayed despite several promising investigations, so, in order to break into the clinical market, existing barriers must be eliminated, and new solutions must be developed. As such, nanotechnology has the potential to help phage formulations overcome their pharmacological drawbacks. The use of nanotechnology to improve phage therapy has received surprisingly little attention in the literature. The key method for increasing phage stability and retention inside the body is encapsulation. New developments in phage therapy using nanotechnology are summarized in this paper. Tweetable abstract Compassionate modern phage therapy holds the promise to cure persistent & incurable illnesses, with improved nano-based delivery technologies increasing success rates. © 2023 Future Medicine Ltd.
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