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Fabrication of Poly(Ε-Caprolactone)/Paclitaxel (Core)/Chitosan/Zein/Multi-Walled Carbon Nanotubes/Doxorubicin (Shell) Nanofibers Against Mcf-7 Breast Cancer Publisher



Bahmani E1 ; Dizaji BF2 ; Talaei S3 ; Koushkbaghi S4 ; Yazdani H1 ; Abadi PGS5 ; Akrami M6 ; Shahrousvand M7 ; Jazi FS8 ; Irani M9
Authors
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Authors Affiliations
  1. 1. Department of Chemical Engineering, Payam Noor University, Tehran, Iran
  2. 2. Faculty of Pharmacy, Eastern Mediterranean University, Famagusta, Turkey
  3. 3. School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Science and Research Branch, Islamic Azad University, Yazd, Iran
  5. 5. Environmental Health Engineering Research Center, Alborz University of Medical Sciences, Karaj, Iran
  6. 6. Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Caspian Faculty of Engineering, College of Engineering, Chooka Branch, University of Tehran, Rezvanshahr, Iran
  8. 8. School of Science and Technology, The University of Georgia, Tbilisi, Georgia
  9. 9. Department of Pharmaceutics, Faculty of Pharmacy, Alborz University of Medical Sciences, Karaj, Iran

Source: Polymers for Advanced Technologies Published:2023


Abstract

In the present study, paclitaxel (PTX), multi-walled carbon nanotubes (MWCNTs), and doxorubicin (DOX) have been simultaneously doped into the poly(ϵ-caprolactone) (PCL)/chitosan/zein core-shell nanofibers to increase its cytotoxicity for MCF-7 breast cancers killing. The physico-chemical properties of synthesized nanofibers were determined by scanning electron microscope, Fourier-transform infrared spectroscopy, tensile strength, and degradation rate determinations. The in vitro release studies demonstrated the sustained release of drugs from core-shell nanofibrous scaffold. The cytotoxicity and compatibility of core-shell nanofibers were investigated by their treating with MCF-7 breast cancer cells and L929 normal cells, respectively. PCL/PTX/chitosan/zein/MWCNTs/DOX core-shell nanofibers containing 1 wt% MWCNTs, 100 μg ml−1 DOX and 100 μg ml−1 PTX had a high biocompatibility with a 84% MCF-7 cancer cells killing. The in vivo studies revealed the synergic effects of MWCNTs and anticancer drugs on the tumor inhibition. This method could be considered as a new way for developing of MWCNTs loaded-nanofibers for cancer treatment in future. © 2022 John Wiley & Sons Ltd.
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