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Micrornas in Cancer Publisher



Mirzaei H1 ; Rahimian N2 ; Mirzaei HR3 ; Nahand JS4 ; Hamblin MR5
Authors
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Authors Affiliations
  1. 1. Kashan University of Medical Sciences, Kashan, Iran
  2. 2. Iran University of Medical Sciences (IUMS), Tehran, Iran
  3. 3. Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. University of Johannesburg, Doornfontein, 2028, South Africa

Source: Synthesis Lectures on Biomedical Engineering Published:2022


Abstract

The dysregulation of microRNAs in cancer was first reported in 2002, when a cluster of two microRNAs (miR16 and miR-15) was detected at chromosome 13q14.3, which had been proposed as one of the commonly eliminated genetic regions in chronic lymphocytic leukemia (CLL) patients [1]. The deletion of this miRNA cluster acts (at least partly) by increasing the expression level of the specific target of miR-15/16, which is the anti-apoptotic protein B cell lymphoma 2 (BCL2). It has been found that micro-RNAs can contribute to each cancer hallmark described by Hanahan and Weinberg [2], as well affecting the clinical progression of many cancers at different stages. © 2022, Springer Nature Switzerland AG.
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