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Micrornas in Cancer Publisher



Mirzaei H1 ; Rahimian N2 ; Mirzaei HR3 ; Nahand JS4 ; Hamblin MR5
Authors

Source: Synthesis Lectures on Biomedical Engineering Published:2022


Abstract

The dysregulation of microRNAs in cancer was first reported in 2002, when a cluster of two microRNAs (miR16 and miR-15) was detected at chromosome 13q14.3, which had been proposed as one of the commonly eliminated genetic regions in chronic lymphocytic leukemia (CLL) patients [1]. The deletion of this miRNA cluster acts (at least partly) by increasing the expression level of the specific target of miR-15/16, which is the anti-apoptotic protein B cell lymphoma 2 (BCL2). It has been found that micro-RNAs can contribute to each cancer hallmark described by Hanahan and Weinberg [2], as well affecting the clinical progression of many cancers at different stages. © 2022, Springer Nature Switzerland AG.
1. Exosomes and Micrornas in Biomedical Science, Synthesis Lectures on Biomedical Engineering (2022)
2. Cancer Genetics at a Glance: The Comprehensive Insights, Cancer Genetics and Psychotherapy (2017)
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