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Emerging Role of Let-7 Family in the Pathogenesis of Hematological Malignancies Publisher Pubmed



Yazarlou F1 ; Kadkhoda S1 ; Ghafourifard S2
Authors
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Authors Affiliations
  1. 1. Department of Medical Genetics, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Biomedicine and Pharmacotherapy Published:2021


Abstract

Let-7 includes a family of miRNA which are implicated in the developmental processes as well as carcinogenesis. This miRNA family has been shown to influence pathogenesis of a variety of hematological malignancies through changing expression of a number of oncogenic pathways, particularly those related with MYC. Expression of these miRNAs has been found to be different between distinct hematological malignancies or even between cytogenetically-defined subgroups of a certain malignancy. In the current review, we summarize the data regarding biogenesis, genomic locations, targets and regulatory network of this miRNA family in the context of hematological malignancies. © 2021 The Authors