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Bioactivity Screening of Mulberry Leaf Extracts and Two Related Flavonoids in Combination With Cisplatin on Human Gastric Adenocarcinoma Cells Publisher



Ghavami G1 ; Muhammadnejad S2 ; Amanpour S3 ; Sardari S1
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Authors Affiliations
  1. 1. Drug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
  2. 2. Cell-Based Therapies Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Cancer Biology Research center, Tehran University of Medical Sciences (TUMS), Tehran, Iran

Source: Iranian Journal of Pharmaceutical Research Published:2020


Abstract

The successful therapy strategy of gastric cancer is defined as devastating the cancerous cells without exposing systematic toxicity and undesirable side effects. One strategy to overcome cancer treatment related difficulties could be combination therapy with natural products with anticancer drugs to introduce effective antitumor effects in addition to reduce undesirable side effects. In this regard, different extracts of mulberry leaf, isoquercetin and rutin as the extracted flavonoids from Morus alba, mulberry, in single dose as well as in combination with cisplatin against gastric cancer cell line were applied. This innovative treatment led to cytotoxic effect on gastric cancer cells in a synergistic manner. The findings anticipated that these herbal products have exceptional potential for future gastric cancer investigations and therapy. © 2020, Iranian Journal of Pharmaceutical Research. All rights reserved.
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