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Extracellular Vesicles: Regenerative Medicine Prospect in Hematological Malignancies Publisher Pubmed



Masoumipour M1 ; Abbaspanah B2 ; Mousavi SH3
Authors
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Authors Affiliations
  1. 1. Department of Medical Laboratory Science, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Cord Blood Bank, Royan Stem Cell Technology Company, Tehran, Iran
  3. 3. Department of Hematology, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran

Source: Cell Biology International Published:2021


Abstract

Extracellular vesicles (EVs) either as endocytic or plasma membrane-emerged vesicles play pivotal role in cell-to-cell communication. Due to the bioactive molecules transformation, lymphoma cell-derived vesicles can alter a recipient cell's function and contribute to signal transduction and drug resistance. These vesicles by acting not only in tumor cells but also in tumor-associated cells have important roles in tumor growth and invasion. On the other hand, the total protein level of circulating exosomes reveals the disease stage, tumor burden, response to therapy, and survival. In residual disease, leukemic blasts are undetectable in the bone marrow by conventional methods but exosomal proteins are elevated significantly. In this manner, new methods for measuring exosomes and exosomal components are required. In this review, we try to reveal the concealed role of EVs in hematological malignancies besides therapeutic potentials. © 2021 International Federation for Cell Biology
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