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Gastrointestinal Cancer Drug Resistance: The Role of Exosomal Mirnas Publisher Pubmed



Salehi M1 ; Vafadar A2 ; Khatami SH3 ; Taherianganeh M2 ; Vakili O4 ; Savardashtaki A2 ; Negahdari B1 ; Naeli P5 ; Behrouj H6 ; Ghasemi H7 ; Movahedpour A6
Authors
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Authors Affiliations
  1. 1. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
  3. 3. Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Centre for Cancer Research and Cell Biology, Queen’s University Belfast, Belfast, United Kingdom
  6. 6. Behbahan Faculty of Medical Sciences, Behbahan, Iran
  7. 7. Abadan University of Medical Sciences, Abadan, Iran

Source: Molecular Biology Reports Published:2022


Abstract

Resistance of gastrointestinal (GI) cancer cells to therapeutic agents are one of the major problems in treating this type of cancer. Although the exact mechanism of drug resistance has not yet been fully elucidated, various factors have been identified as contributing factors involved in this process. Several studies have revealed the role of exosomes, especially exosomal microRNAs (miRNAs), in GI tumorigenesis, invasion, angiogenesis, and drug resistance. Exosomes, a type of small extracellular vesicles (EVs), are originated from endosomes and are released into the extracellular environment and body fluids by different cell types. Exosomes mediate cell–cell communication by transferring different cargos, including miRNAs, between parent and recipient cells. Therefore, identifying these exosomal miRNAs and their functions in GI cancers might provide new clues to further explore the secret of this process and thus help in drug-resistance management. This review article will discuss the roles of exosomal miRNAs and their mechanisms of action in drug resistance of different types of GI cancer cells (e.g., stomach, esophagus, liver, pancreas, and colon) to therapeutic agents. © 2021, The Author(s), under exclusive licence to Springer Nature B.V.
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